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Pyroptosis, a lytic form of cell death mediated by the gasdermin family, is characterized by cell swelling and membrane rupture. Inducing pyroptosis in cancer cells can enhance antitumor immune responses and is a promising strategy for cancer therapy. Ho
The previous curation system for G2P relied on experienced clinical geneticists and scientists making expert judgements to form LGMDE threads. This was based on careful review of the primary literature and manual population of the data fields contained within G2P [2]. The process was not standar...
For example, OXD-CAT-POD-like nanozymes, can form OXD-POD and CAT-OXD two kind of cascade catalytic systems. The nanozymes utilized its POD- CAT-like activity to catalyze the generation of HO· and O2. O2 was further utilized by its OXD-like activity to generate O2−·. The HO· ...
DNA replication begins with the licensing of replication origins through binding of the origin recognition complex to chromatin, which will subsequently recruit the key licensing factors Cdc6 and Cdt1. In turn, this machinery will recruit the replicative helicase MCM complex, forming the pre-...
In recent years, considerable research on pyroptosis has been conducted in the field of nanozymes. This form of programmed cell death, characterized by its inflammatory response, is being increasingly explored for its potential applications in targeted cancer therapies, utilizing nanozymes to selectively ...
plaque and media; SMCs were only located in the media and were located in the plaque and media; B cells were distributed in part of blood vessels; endothelial cells were thought to be scattered in the blood vessels in a small amount and could not form a continuous membrane-type structure....
Autoantibodies are a form of antibody which react with substances formed by a person’s own body (i.e., self-antigens) [96]. These self-antigens can be exclusive for a specific-cell type within one organ of the body or can be found in all cell-types, such as chromatin or centromere...