Full form orSAP QMstands for(Quality Management), a consistent and comprehensive component that helps organizations implement'corrective and preventive actions (CAPA)'; brings about reductions in supply network expenses; streamlines the processes of"quality issue management (QIM)"and lays down the righ...
The aging of the central nervous system(CNS) is a primary contributor to neurodegenerative diseases in older individuals and significantly impacts their quality of life. Neuroinflammation, characterized by activation of microglia(MG) and release of cytokines, is closely associated with the onset of thes...
Several case reports demonstrating the clinical efficacy of PARPi in endometrial/uterine carcinoma cases have been published in recent years [24,25,26] leading to the establishment of clinical trials investigating the efficacy of the PARPi, niraparib, rucaparib or olaparib, in advanced / ...
ADCs, which represent a form of targeted chemotherapy, hold promise in overcoming platinum resistance in ovarian cancer treatment. They are increasingly being explored in combination with other agents and are even being considered as first-line therapeutic options [25]. Currently, over 100 ADCs are ...
Although both enzymes catalyze the same reaction, TDO is primarily found in the liver, whereas IDO is widely distributed in various other tissues. Subsequently, N-formyl-L-kynurenine goes through four different consecutive enzymatic reactions to form the intermediate α-amino-β-carboxymuconate-ε-...
In response to these criticisms, there have been attempts to transform services using initiatives such as the Choice and Partnership Approach (CAPA) [12], CYP-IAPT (an analogue of the adult Improving Access to Psychological Therapies initiative for children and young people) [13] and ‘THRIVE’...
The severity of sarcopenia would then be defined by changes in strength, muscle quantity/quality, and poor functional performance assessed by Gait Speed (GS), Short Physical Performance Battery (SPPB), or Timed Up and Go test (TUG) [1]. Recent estimates suggest that the overall ...
Ovarian cancer (OC) remains one of the most challenging and deadly malignancies facing women today. While PARP inhibitors (PARPis) have transformed the treatment landscape for women with advanced OC, many patients will relapse and the PARPi-resistant set
Thermally degraded engine oil and hydraulic fluid fumes contaminating aircraft cabin air conditioning systems have been well documented since the 1950s. Whilst organophosphates have been the main subject of interest, oil and hydraulic fumes in the air su
There are also other biomarkers proposed for the LS screening, as blood sampling is not the only form of liquid biopsy providing ctDNA. Mutations in the telomerase reverse transcriptase (TERT) promoter and the fibroblast growth factor receptor 3 (FGFR3) are often found in LS. These alterations...