This is not a comprehensive guide on corrective action and preventive action (CAPA) for a specific industry like a medical device, pharma, etc., but a simplified overview of CAPA, with an example of various industries. Always follow the standards applicable to you and your company! What is C...
Mutations in BET protein changes the protein conformation and alters the biological processes mediated through either protein-protein or DNA-protein interactions leading to initiation and progression of tumor [128,129]. Haendler et al., from Bayer pharma reported the synthesis of 5-aryltriazoloazepine...
in PARP inhibition in surrogate normal tissues (peripheral blood mononuclear cells, or PBMCs) and tumor biopsies was observed, and a PARP-inhibitory dose (PID) of 12mg/m2was not toxic with full-dose TMZ. AG014699 at the PID caused around 90% PARP inhibition in the tumors.Myelosuppression...