Epicardium, the most outer mesothelium, exerts crucial functions in fetal heart development and adult heart regeneration. Here we use a three-step manipulation of WNT signalling entwined with BMP and RA signalling for generating a self-organized epicardi
relations in the graph is incident to other pairs of entity types, then the resulting embeddings are likely not optimised to predict links between compounds and diseases. We propose a method that leverages domain knowledge in the form of metapaths and use them to filter two biomedical knowledge ...
Acute myeloid leukemia (AML) is a fatal hematopoietic malignancy and has a prognosis that varies with its genetic complexity. However, there has been no appropriate integrative analysis on the hierarchy of different AML subtypes. Using Mic
Fusobacterium nucleatum (Fn) acts as a procarcinogenic bacterium in colorectal carcinoma (CRC) by regulating the inflammatory tumor microenvironment (TME). Neutrophil extracellular traps (NETs), which can be generated by persistent inflammation, have bee
However, the anti-cancer efficacy of PF-543 has not yet been investigated in primary cancer models in vivo, thereby limiting its further translation. Methods Building upon the identification of the active form of SphK1 as a viable therapeutic target in human HCC specimens, we assessed the ...
The first release of AtcisDB (AtcisDB 1.0) contains an annotation of the promoter sequences for all 27,975 annotated Arabidopsis genes. AtcisDB is linked to AtTFDB when binding sites for specific transcription factors have been identified. Together, AGRIS provides a first step in establishing ...
Sxl in female acts on the pre-mRNA of transformer (tra) resulting in reproduction of functional Tra. The functional Tra in the female, in concert with Tra-2, regulates the production of female-specific doublesex (dsx) mRNA. The male-specific splice form of dsx mRNA is the default splice-...
Perhaps the most prominent of these transcription factors, is NFκB. NFκB represents a family of related proteins which dimerize to form transactivating complexes [35]. NFκB dimmers are sequestered in the cytoplasm by interaction with inhibitory proteins (the IκBs). Various stimuli activate ...
MaxL and Myc-MaxL displayed tight binding to CACGTG (Kds of 0.4 nM and 0.1 nM, respectively) (Figure 3D). MaxL did not form a discrete complex with the ATCTAG probe with the concentrations of protein tested (Kd >1 ?M), but instead gave only a smeary band below the position of a...
in environmental conditions and a considerable proportion of precipitation as rain [13,14]. In the continental Antarctica, precipitation occurs almost entirely in the form of snow and is often extremely limited. In some parts of the continent where low atmospheric humidity is typical, much of this...