Epicardium, the most outer mesothelium, exerts crucial functions in fetal heart development and adult heart regeneration. Here we use a three-step manipulation of WNT signalling entwined with BMP and RA signalling for generating a self-organized epicardi
The gene regulatory information is hardwired in the promoter regions formed by cis-regulatory elements that bind specific transcription factors (TFs). Hence, establishing the architecture of plant promoters is fundamental to understanding gene expression
Acute myeloid leukemia (AML) is a fatal hematopoietic malignancy and has a prognosis that varies with its genetic complexity. However, there has been no appropriate integrative analysis on the hierarchy of different AML subtypes. Using Mic
Tele-Kasper is a stepped-wedge cluster-randomized trial that will be conducted across non-university children’s hospitals in Germany. The intervention consists of a telemedical consultation service in the form of a network in different German areas, using an app as a communication tool. The ...
biomedicines Review Both Full-Length and Protease-Cleaved Products of Osteopontin Are Elevated in Infectious Diseases Toshio Hattori 1,* , Hiroko Iwasaki-Hozumi 1 , Gaowa Bai 1 , Haorile Chagan-Yasutan 1,2, Ashwnini Shete 3 , Elizabeth Freda Telan 4, Atsushi Takahashi 1, Yugo Ashino 5 ...