State of the art in total body PET. EJNMMI Phys. 2020; 7(1):35. 2. Mariele Stockhoff, Milan Decuyper, Roel Van Holen, Stefaan Vandenberghe. High-resolution monolithic LYSO detector with 6-layer depth-of-interaction for clinical PET. Phys Med Biol. 2021; 66(15):https://doi.org/...
Neutral benchmarking shares common ground with community “challenges” for consolidating the state-of-the-art. In some subfields of computational biology, there is a long history of such challenges, such as the biannual CASP (Critical Assessment of Structure Prediction) [13] and DREAM (Dialogue ...
The simplest Poisson model of the form (3) is one in which θij is the same across all cells i, that is, θij=pj0 for all i=1,…,n. We treat this a “null” model, which can be used to make certain comparisons, e.g., to estimate changes in expression in relative to express...
While particular strains within the Bacillus species, such as Bacillus subtilis, have been commercially utilised as probiotics, it is critical to implement screening assays and evaluate the safety to identify potential Bacillus probiotic strains before c
The switch to osteoclast differentiation requires expression in osteoclast precursors (OCPs) of c-Fos, a RANKL activated transcription factor [3]. To resorb bone effectively, osteoclasts attach themselves firmly to the bone surface using specialized actin-rich podosomes, which they use to form tightly...
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In contrast, TPpred-LE is the only method for comprehensively predicting 15 different therapeutic peptide functions. The performance of TPpred-LE is measured by binary classification metrics and compared with the state-of-the-art binary classification methods for therapeutic peptide prediction, including...
Synapses are essential parts of neurons that form the requisite connections of the neuronal networks that underlie cognition. The cognitive impairment in AD closely parallels the loss of synapses due to the toxic effects of Aβ, tau, and inflammation. Emerging biomarkers of synapse damage reflect su...
of the eighteenth century, but in more modern times, Dr. Albert Sabin developed the oral polio vaccine jointly with his Soviet Russian counterparts during some of the toughest years of the Cold War (Hotez2014,2021). I aspired to replicate this accomplishment in some twenty-first century form....
Spinal muscular atrophy (SMA) is a devastating neuromuscular disease caused by hypomorphic loss of function in the survival motor neuron (SMN) protein. SMA presents across a broad spectrum of disease severity. Unfortunately, genetic models of intermediat