Historically, chemical modifiers of radiation effect have had little impact on overall average survival times in human trials of brain metastases. Misonidazole, bromodeoxyuridine (BUdR), lonidamine, nimustine, fluorouracil, and others have failed to show significant benefit in randomized trials [19–26...
Full Frame: Mapping the Brain The three-pound organ that is the human brain is the command center for our thoughts, feelings, memories, behaviors and motor skills. Yet so much about it is still a mystery. Dr. Sergiu Pasca has made it his life’s work to understand how the brain builds...
[2] The standard of care (SOC) for grades 3 or 4 high-grade gliomas (HGGs) including GBM, a grade 4 glioma, currently relies on maximally safe surgical resection followed by concurrent radiation therapy and temozolomide (TMZ). [4] While this SOC has increased the median survival time of...
During the enrolment process, we plan to collect demographic information, including age, height, weight, blood pressure, heart rate, past medical history, smoking history, and laboratory parameters such as leukocytes, neutrophils, creatinine, uric acid, myocardial enzymes, pro-brain natriuretic peptide...
The spinal dorsal horn is the first transit point for pain signals, which are transmitted to the dorsal horn of the spinal cord and subsequently to the upper brain centers, thus creating conscious pain. Numerous studies have shown that considerable amounts of pain are mediated by both central ...
reported that single-session SRS with frameless immobilization head-neck mask tomotherapy was a feasible and safe treatment option for patients with brain metastases, with a good overall response rate and acceptable toxicity. Among toxicities, radiation-related white matter changes (WMC) were detected ...
The development and clinical application of such a method would markedly increase the survival rate and reduce the severity of subsequent disability by enabling much earlier treatment at the point of first patient contact. To test the viability of this concept, we modified the target model to ...
The in vitro radiosensitization effect of CDKL1 was evaluated using a neutral comet assay, γH2AX foci formation analysis, and a clonogenic cell survival assay. The protein‒protein interactions were confirmed via coimmunoprecipitation and GST pulldown assays. The regulation of PD-L1 by CDKL1 was...
Med4way can be used when the outcome is continuous, dichotomous, count, or survival time, and the mediator is continuous or binary. This method assumed that the total effect (TE) of social support on cognitive impairment can decompose into four components: the controlled direct effect (CDE, ...
Brain-derived neurotrophic factor (BDNF) is a very well-studied neurotrophin. BDNF plays an important role in the development and maintenance of brain function by mediating neuron survival and function.BDNFmRNA expression and BDNF immunoreactivity have been measured in the cortex, hippocampus, and amyg...