West, Char- acterization of a cytosolic fucosylation pathway in Dictyostelium, J. Biol. Chem. 267 (1992) 9595 - 9605.Gonzalez-Yanes, B., J. M. Cicero, R. D. Brown, and C. M. West. 1992. Characterization of a cytosolic fucosylation pathway in Dictyostelium. J. Biol. Chem. 267:9595...
To identify melanoma proteins that contributed to fucosylation-triggered, CD4+ T cell-mediated melanoma suppression, we subjected fucosylated proteins from human melanoma cells to liquid chromatography–mass spectrometric (LC–MS/MS) analysis followed by Ingenuity Pathway Analysis21 (Extended Data Fig. 3a...
Cell line HCT116 has a mutation in the fucosylation pathway and is therefore expected to have low fucosylation. Splitting the total fucosylation in mono-fucosylation (one fucose) and multi-fucosylation (2–5 fucoses, indicative for the presence of Lewis-type antigens) revealed mono-fucosylation ...
O-fucose glycans of Notch was essential for Notch signaling pathway to involve in the regulation of embryo development [49, 50]. Although studies have revealed that fucosylated specific scaffold proteins were related to the biological process in embryo implantation, the landscape of fucosylation ...
Characteristics Finding of Fucosylation-Deficient Cancer Cell Lines GDP-fucose is synthesized in cytosol via de novo and salvage pathways. In the de novo pathway, which plays a major role in the GDP-fucose synthesis of many cells,...
Is one of the most popular modifications witholigosaccharideson glycoproteins or glycolipid, which is involved in cancer. Fucosylation involves the attachment of a fucose residue toN-glycans,O-glycans, and glycolipids.O-fucosylation, which is a special type of fucosylation, is very important forNotch...
Basically, fucosyltransferases, GDP-fucose synthetic enzymes, and GDP-fucose transporters are involved in the fucosylation pathway. There are 11 diffe ... 展开 DOI: 10.1007/978-3-540-47648-1_2272 年份: 2008 收藏 引用 批量引用 报错 分享 ...
E., Human symbionts use a host-like pathway for surface fucosylation. Science 2005, 307, 1778-1781. :Coyne, M. J., Reinap, B., Lee, M. M.,... dLECM Brinkman-Van - 《Journal of Biological Chemistry》 被引量: 249发表: 2000年 ...
PKC蓻-phosphorylated ATF2 transcriptionally represses fucokinase (), a key upstream regulatory kinase of the fucose salvage pathway, which directs the conversion of L-fucose to GDP-L-fucose that is used to fucosylate proteins in cells. Primary melanocytes and early stage melanoma cell lines ...
cell-permeable fucose derivatives which are metabolized to the corresponding active GDP-fucose analogs through thesalvage pathway5,6,7,8,9. These compounds target FucTs by competitive inhibition and the de novo enzymes GMDS and FX by feedback inhibition. This strategy led to fucosylation inhibitors...