TREM2 boosting therapies rely on the development of biomarkers, which allow to monitor target engagement, efficacy of treatment and even stratification of patients with low or high microglial response. Therefore, biomarkers are required, which allow the determination of microglial responses to ...
The first reports of disorders that in terms of cognitive and behavioral symptoms resemble frontotemporal dementia (FTD) and in terms of motor symptoms resemble amyotrophic lateral sclerosis (ALS) bring us back to the second half of the 1800s. Over the last 150 years, and especially in the ...
There are no cures for FTD, and treatment focuses on symptom management. Behavioral symptoms are sometimes managed with antidepressants, antipsychotics, or mood stabilizers, though caution is needed due to side effects. For language deficits, speech therapy may offer some improvement, while physical th...
10 both significantly reduced sense repeat transcript levels by ~40%, dependent on the cell line used, relative to the non-targeting gRNA control (Fig.2c). Similarly, our antisense targeting gRNAs 11 and 17 successfully reduced the antisense repeat-containing transcripts in all threeC9orf72ALS/...
inappropriate behaviour - Psychiatric symptoms, depression and anxiety common - Memory, motor function and perception are relatively preserved until late disease stages BIBD - Significant FUS-pathology plus subcortical basophilic inclusions on H&E staining ALS Amyotrophic Lateral Sclerosis (familial and spora...
Despite the wide range of genes and cellular functions involved, all familial and sporadic ALS patients present with almost indistinguishable clinical symptoms, regardless of the primary cause of the disease. This suggests that all these different pathways may converge onto a common mechanism of ...
administration of Akkermansia muciniphila was associated with improvements of symptoms and prolonged survival whereas Ruminococcus torques and Parabacteroides distasonis were associated with an exacerbation of disease progression. In addition, preliminary analyses of human gut microbiota further supported the hypo...
symptoms [122]. While not fully understood, it could be that PVMs are acting as antigen-presenting cells that are able to reactivate T cells as they cross the blood–brain barrier [122]. Although not yet studied in animal models of ALS, these additional myeloid cells may play a role in...
Although ALS has long been considered a motor neuron disease, some ALS patients have symptoms of frontotemporal dementia (FTD). The two disorders share many pathological and genetic features as well as several dysfunctional molecular pathways downstream of many common disease-causing genetic Drosophila ...
administration of Akkermansia muciniphila was associated with improvements of symptoms and prolonged survival whereas Ruminococcus torques and Parabacteroides distasonis were associated with an exacerbation of disease progression. In addition, preliminary analyses of human gut microbiota further supported the hypo...