There are no cures for FTD, and treatment focuses on symptom management. Behavioral symptoms are sometimes managed with antidepressants, antipsychotics, or mood stabilizers, though caution is needed due to side effects. For language deficits, speech therapy may offer some improvement, while physical th...
Typical symptoms include hand and leg weakness, loss of ability to initiate/control movements, and slurred speech. This disorder is marked by the loss of motor neurons in the brain and spinal cord, and atrophy of the frontal and temporal lobes. The majority of pathogenic mutations are present ...
We present three cases of bvFTD-like symptoms reported by spouses, where progression was unclear, testing showed mild but stable executive dysfunction, and neuroimaging was unremarkable. The subjective nature of bvFTD criteria leaves patients vulnerable to misleading informant reports, especially amid ...
Frontotemporal dementia (FTD) is an insidious neurodegenerative disease characterised by progressive deficits in behaviour and cognition. FTD is a common type of dementia, particularly in patients younger than 65 years. It is the second most common form of younger-onset dementia after Alzheimer’s dis...
Firepower appliances provide multiple capture points that provide visibility into the transit flows. When you troubleshoot and enable cluster captures the main challenges are: The number of captures increases as the number of units in the cluster increase. ...
symptoms [122]. While not fully understood, it could be that PVMs are acting as antigen-presenting cells that are able to reactivate T cells as they cross the blood–brain barrier [122]. Although not yet studied in animal models of ALS, these additional myeloid cells may play a role in...
administration of Akkermansia muciniphila was associated with improvements of symptoms and prolonged survival whereas Ruminococcus torques and Parabacteroides distasonis were associated with an exacerbation of disease progression. In addition, preliminary analyses of human gut microbiota further supported the hypo...
Numerous kindreds with familial frontotemporal dementia or amyotrophic lateral sclerosis or both have been linked to chromosome 9 (c9FTD/ALS), and an expansion of the GGGGCC hexanucleotide repeat in the non-coding region of chromosome 9 open reading frame 72 (C9ORF72) was identified in the summ...
A repeat expansion in the C9orf72 (C9) gene is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Here we investigate single nucleus transcriptomics (snRNA-seq) and epigenomics (snATAC-seq) in postmortem motor and frontal cortices from C9-ALS...
, language disorders, loss of executive control, and motor symptoms7. Both ALS and FTD are aggressive diseases with no current treatments that significantly slow disease progression or extend life expectancy8. TheC9ORF72gene locus produces three protein-coding RNA transcript variants, V1, V2, and...