Insulin resistanceInflammationMetabolic syndrome (MetS)Gut microbiotaHerbal medicineBiomarkersThe brainEthanolHumansOxidative stressGlucose is a major energy source for the entire body, while fructose metabolism occurs mainly in the liver. Fructose consumption has increased over the last decade globally and ...
In this article, we address this question in the context of fructose metabolism and provide our unbiased view of whether excessive fructose consumption is a contributing factor for fueling the development of insulin resistance and fatty liver disease. 展开 ...
Increased free fatty acids in the circulation can also induce fatty liver and adipose accumulation, and reduce the response to insulin thereby causing IR [3]. A high flux of fructose to the liver, the main organ capable of metabolizing this simple carbohydrate, perturbs glucose metabolism and ...
Accordingly, our data demonstrated that HIO may have a pathogenic role in the onset of liver steatosis and insulin resistance. Moreover, distinct mechanisms, in addition to hepcidin, may underlie NAFLD-related HIO. These data suggest that the HFHFr diet can be used for establishing a suitable ...
et al. Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver. J. Lipid Res. 53, 1080–1092 (2012). Article CAS PubMed PubMed Central Google Scholar Jakobsen, S. et al. A PET tracer for renal organic cation transporters, 11C-metformin: ...
The researchers analyzed different known markers of fatty liver to determine the effects of each diet. For example, they looked at levels of acylcarnitines in the liver's cells. Acylcarnitines are produced when the liver burns fats. High levels of these are a bad sign, since it means there...
Western dietary habits are partially characterized by increased uptake of fructose, which contributes to metabolic dysregulation and associated liver diseases. For example, a diet enriched with fructose drives insulin resistance and non-alcoholic fatty liver disease (NAFLD). The molecular hubs that control...
Either way, the person feels the urge to eat more, resulting in weight gain and increased fat deposits. Deposition of fat in the liver leads to non-alcoholic fatty liver disease (NAFLD). Addiction to sweets: It is believed that fructose may lead to addiction to sweet food. Glucose activat...
Study results show that fructose stimulatesfood intakeand lowers resting energy metabolism, much like an animal preparing to hibernate. Further, results show that the administration of fructose can lead to weight gain,insulin resistance, elevated blood pressure and fatty liver among a host of other ...
Fructose, weight gain, and the insulin resistance syndrome.Fructose-induced insulin resistance and hypertension in rats.Fructose consumption as a risk factor for non-alcoholic fatty liver disease ☆Metabolic Effects of Fructose and the Worldwide Increase in ObesityA causal role for uric acid in fruct...