Molecular mechanisms of hepatic insulin resistance in a fructose-fed/insulin resistant hamster modeldoi:10.1016/S0009-9120(00)00129-6C TaghibiglouS Van-IderstineB ChenK AdeliElsevier Inc.Clinical Biochemistry
In addition, there was increased Nrf2 expression accompanied by low SOD1 expression in the liver, suggesting that HFFD may induce hepatic insulin resistance and subsequent steatosis through the enhancement of increased free fatty acid influx into the portal system and hepatic oxidative stress [21, 22...
Finally, promising drugs against fructose-induced insulin resistance and hepatic dysfunction that are emerging from studies in rodents are reviewed, but need further validation in human patients. 展开 关键词: Insulin resistance Inflammation Metabolic syndrome (MetS) Gut microbiota Herbal medicine Biomarkers...
5.1. Fructose and Hepatic Insulin Resistance Hepatic lipid accumulation in the context of NAFLD is often associated with hepatic insulin resistance [126–134], and NAFLD is considered an important risk factor for type 2 diabetes [11]. Emerging evidence points to the accumulation of specific ...
Fructose: a highly lipogenic nutrient implicated in insulin resistance, hepatic steatosis, and the metabolic syndrome. past 40 years, there is growing concern that high fructose consumption in humans may be in part responsible for the rising incidence of obesity worldwide... MJ Dekker,Q Su,C Bak...
Obese individuals and obese patients with non-insulin-dependent diabetes mellitus commonly have a decrease in glucose-induced thermogenesis. These individuals in contrast display a normal thermogenesis after ingestion of fructose. This may be explained by the fact that the initial hepatic fructose ...
Toll-like receptor 4 is involved in the development of fructose-induced hepatic steatosis in mice. A link between dietary fructose intake, gut-derived endotoxemia, and nonalcoholic fatty liver disease (NAFLD) has been suggested by the results of human an... A Spruss,G Kanuri,S Wagnerberger,...
[130]. The acute fructose infusion induced both extra hepatic and hepatic insulin resistance, which has been suggested to be secondary to an increased intrahepatic glucose 6-phosphate synthesis. These results raise questions as to whether ingested fructose as part of the diet may have the same ...
Fructose and metabolic health: governed by hepatic glycogen status? Fructose is a commonly ingested dietary sugar which has been implicated in playing a particularly harmful role in the development of metabolic disease. Fru... A Hengist,F Koumanov,JT Gonzalez - 《Journal of Physiology》 被引量:...
This ChREBP/G6PC signaling axis is conserved in humans. Together, these findings support a carbohydrate-mediated, ChREBP-driven mechanism that contributes to hepatic insulin resistance. 展开 DOI: 10.1172/JCI81993 被引量: 42 年份: 2016