Fructose-1,6-bisphosphataseInhibitorGluconeogenesisDiabetesQSARGlucoseThe rising incidence of diabetes and confines allied with clinical therapies emphasized the need to explore new molecular targets to develop novel, effective and safer antihyperglycemic agents. Excessive endogenous glucose production by ...
G6PC, glucose-6-phosphatase, catalytic subunit; PCK1, phosphoenolpyruvate carboxykinase 1; FBP1, fructose-1,6-bisphosphatase 1. c, Illustration of central carbon metabolism, including glycolysis, gluconeogenesis, pentose phosphate pathway, and the TCA cycle. Enzymes controlling glycolysis (HK, ...
from which gluconeogenesis must start2,3,4. Here we show that virtually all archaeal groups as well as the deeply branching bacterial lineages contain a bifunctional fructose 1,6-bisphosphate (FBP) aldolase/phosphatase with both FBP aldolase and FBP phosphatase activity. This enzyme is missing in ...
Fructose-1,6-Bisphosphatase 1 (FBPase 1) is a member of the FBPase class 1 family. FBPase 1 is a gluconeogenesis regulatory protein, which catalyzes the hydrolysis of fructose 1,6-bisphosphate to fructose 6-phosphate and inorganic phosphate. FBPase 1 can assume an active R-state, or an inac...
What are the uses of Fructose 1,6-bisphosphatase?Fructose 1,6-bisphosphatase (FBPase) is a vital enzyme involved in regulating gluconeogenesis, the process of producing glucose from non-carbohydrate sources. This enzyme plays a crucial role in maint.. Why is Fructose a Reducing Sugar?Many people...
A hydrolase that catalyzes conversion of fructose 1,6-bisphosphate tod-fructose 6-phosphate and orthophosphate in gluconeogenesis; AMP is an allosteric inhibitor; fructose-bisphosphatase deficiency results in problems with impaired gluconeogenesis; there is a similar enzyme that acts on fructose 2,6-bisph...
Fructose 1,6-bisphosphatase-1 Inhibitor is a fructose 1,6-bisphosphatase-1 inhibitor. Fructose 1,6-bisphosphatase-1 (FBPase-1), an enzyme catalyzing the conversion of fructose-1,6-bisphosphate to fructose 6-phosphate, is one of the rate-limiting steps in gluconeogenesis. Excess hepatic fructose...
Fructose 1,6-bisphosphatase (FBPase) is a key enzyme in gluconeogenesis. It is a potential drug target in the treatment of type II diabetes. The protein is also associated with a rare inherited metabolic disease and some cancer cells lack FBPase activity which promotes glycolysis facilitating the...
6‐bisphosphatase deficiencyFBP1Fructose‐1HypoglycemiaMutationStatus epilepticusFructose‐1,6‐bisphosphatase ( ase) deficiency is a rare inherited disorder in gluconeogenesis, characterized by hypoglycemia, ketonuria, metabolic acidosis and convulsions.
Fructose-1,6-bisphosphatase (FBP1) is often known as a rate-limiting enzyme in gluconeogenesis. Recently, its catalytic activity-independent function, repr... X Ning,T Li,S Peng,... - 《Translational Andrology & Urology》 被引量: 0发表: 2015年 In vivo protein-DNA interactions on a glucoc...