Here we demonstrate that telomerase activity is differentially regulated in cancer and normal cells depending on the expression status of fructose-1,6-bisphosphatase 1 (FBP1). In FBP1-expressing cells, FBP1 directly interacts with and dephosphorylates telomerase reverse transcriptase (TERT) at Ser227...
fructose 1,6-bisphosphatasenuetral enzyme propertiesneutral fru-p 2 aselysosomesregulation and physiological functionSummary This chapter contains sections titled: Introduction Isolation of Neutral Fru-P 2 ase Properties of Neutral Fru-P 2 ase Conversion of Neutral Fru-P 2 ase to the Alkaline Form ...
Conversion of Neutral to Alkaline Fructose 1,6-Bisphosphatase by Proteolytic Mechanisms: Structure-Function RelationshipDigestion of native fructose 1,6-bisphosphatase (Fru-P 2 ase) with subtilisin determines the removal of a tryptophan-containing peptide from the amino-terminal region of each of the ...
Fructose-1,6-bisphosphatase is shown to be depleted in clear cell renal cell carcinoma (ccRCC) and inhibits ccRCC progression by antagonizing glycolytic flux in renal tubular epithelial cells and by restraining cell proliferation, glycolysis, and the pen
Background : Disturbances in the function of renal proximal tubules increase the activity of several enzymes in urine. Among them is fructose-1,6-bisphosphatase (FBP-1), the key enzyme of gluconeogenesis normally present in the renal convoluted, and to s
Fructose-1,6-bisphosphatase was precipitated with purified rabbit antiserum from extracts of 32P-orthophosphate labelled yeast cells, submitted to SDS polyacrylamide gel electrophoresis, extracted from the gels and counted for radioactivity due to 32P incorporation. Fructose-1,6-bisphosphatase from glucose ...
The inhibitory effect of fructose 2,6-biphosphate on fructose 1,6-bisphosphatase was reinvestigated in order to solve the apparent contradiction between co... Jean FRANOIS,EV Schaftingen,HG Hers - 《European Journal of Biochemistry》 被引量: 504发表: 1983年 ChemInform Abstract: Synthesis of Analo...
Hence the activation by EDTA of the Mg2+and Mn2+assays is explicable in terms of Zn2+removal, thus eliminating mixed metal species. Collectively these observations suggest that fructose-1,6-bisphosphatase may function in vivo as a Zn2+metalloprotein. 展开 ...
Gontero B, Meunier JC, Buc J, Ricard J (1984) The ‘slow’ pH-induced conformational transition of chloroplast fructose 1,6-bisphosphatase and the control of the Calvin cycle. Eur J Biochem 145:485–488Gontero, B., Meunier, J.-C., Buc, J., Richard, J. (1984) The slow pH induced...
Subtilisin catalyzes a limited modification of rabbit liver fructose 1,6-bisphosphatase (Fru-P2ase, EC 3.1.3.11), resulting in enhanced catalytic activity measured at pH 9.2. Sequence analysis of a cyanogen bromide peptide containing the subtilisin cleavage sites and of the NH2-terminal portion of ...