frataxin蛋白细胞定位 主要定位于线粒体:Frataxin蛋白主要存在于细胞的线粒体中。线粒体作为细胞的能量工厂,承担着有氧呼吸和ATP合成等重要功能。通过免疫荧光标记和共聚焦显微镜技术观察发现,Frataxin蛋白与线粒体特异性标志物如线粒体膜电位染料JC-1共定位,共定位系数高达0.8 - 0.9,这表明超过80% - 90%的Frataxin...
1、本公开提供可以用于治疗弗里德赖希共济失调的组合物和方法。使用本公开的组合物和方法,可以向患有弗里德赖希共济失调的患者(例如哺乳动物患者,诸如人类患者)施用含有人frataxin基因(hfxn)或它的rna等效物的质粒(例如,病毒载体)。 2、一方面,本公开提供一种编码hfxn或它的rna等效物的dna多核苷酸,其中所述多核苷酸...
Frataxin is produced from the most abundant FXN transcript derived from exons 1–5a (Campuzano et al., 1996). Frataxin is most highly expressed in dorsal root ganglia, the spinal cord, cerebellar dentate nuclei, cerebral cortex, pancreas, heart, liver and skeletal muscle (Campuzano et al....
文章的通讯作者是来自美国德州农工大学的David P. Barondeau. Frataxin(FXN)是一种与铁硫簇(Fe-S)生物合成以及线粒体功能相关的蛋白质,其基因下调会导致无法治愈的神经退行性疾病FRDA。由于FXN在Fe-S簇装配过程中的确切作用未被系统阐明,通过改变FX...
Frataxinis a smallmitochondrial proteinwhose exact function has been the focus of intense studies for the last decade since the identification of theFRDAgene[1]. Several functions have been proposed forfrataxinincluding a role in the biogenesis of heme and iron–sulfur clusters (ISCs)[9–18], mi...
报告对Frataxin线粒体行业的过去五年市场规模和增长率进行了详尽统计,并预测了未来的发展前景。数据显示,2024年全球和中国Frataxin线粒体市场规模分别达到 亿元和 亿元。基于市场增长模式,报告预测全球Frataxin线粒体市场将以 %的年复合增长率增长,到2030年达到 亿元。
英文名 Frataxin (FXN) 英文别名 Frataxin (FXN) 您刚刚浏览过 Frataxin (FXN) 刚刚更新的化工产品 55635-72-8 853574-50-2 75963-92-7 101277-12-7 53510-47-7 294636-40-1 66762-15-0 93500-63-1 89378-32-5 61716-54-9 121742-56-1 142952-66-7 72851-40-2 65111-05-9 62160-62-7...
14147-1-AP targets Frataxin in WB, IHC, IF, CoIP, ELISA applications and shows reactivity with human, mouse, rat samples. Tested Applications WB, IHC, ELISA Application Description Cited Applications WB, IHC, IF, CoIP Tested Reactivity human, mouse, rat Cited Reactivity human, mouse, rat Im...
Frataxin (FXN) - Names and Identifiers Home Product Category Frataxin (FXN) Home CAS CAS CAS NameFrataxin (FXN) SynonymsFrataxin (FXN)
have been used to address this issue and are summarized in the following.Frataxin, a mitochondrial protein defective inFriedreich ataxia, is known to increaseoxidative metabolismand ATP synthesis[140]probably by interacting withrespiratory chaincomponents[141]and/or by regulating the synthesis of Fe/S...