The Fo-CHI has been demonstrated to arise in individuals who have a germline mutation in the paternal allele of ABCC8 or KCNJ11 in addition to a somatic loss of the maternally derived chromosome region 11p15 in adenomatous pancreatic 尾-cells, while Di-CHI predominantly arises from the ...
One might suspect that the observation might be explained by relaxed selection of the derived copy, but this should not be the case, due to a low Ka/Ks ratio in the common frame region (Ka/Ks = 0.27), indicating that the Ka/Ks ratio was elevated only in the frameshifted region, and...