FOXP4PI3K/AKT信号通路目的研究FOXP4-AS1在甲状腺乳头状癌(PTC)组织中表达水平及其与临床病理特征之间的关系;明确FOXP4-AS1在PTC中的具体生物学功能,并初步探究其可能的作用机制.方法(1)生物信息学筛选FOXP4-AS1和甲状腺癌预后的相关性:下载GEO数据库(GENE EXPRESSION OMNIBUS)的GSE66783数据集,并从癌症基因组图谱(...
目的 探讨长链非编码 RNA(lncRNA)FoxP4-AS1 在甲状腺乳头状癌(PTC)中的表达情况及其与淋巴结转移的相关性。方法 采用实时荧光定量聚合酶链反应法检测 52 例 PTC 癌组织及其对应的癌旁组织,以及 PTC 细胞(TPC-1、B-CPAP、K1 细胞)和正常甲状腺滤泡上皮细胞(Nthy-ori3-1 细胞)中 FoxP4-AS1 的表达情况。采用...
Functionally, high FOXP4-AS1 level was associated with increased cell proliferation and decreased cell apoptosis, indicating that FOXP4-AS1 exerted oncogenic functions in the tumorigenesis of PCa. Furthermore, FOXP4-AS1 was located in the cytoplasm of PCa cell lines and positively regulated FOXP4. ...
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目的FOXP4-AS1(FOXP4 反义 RNA 1)被认为是结直肠癌中的功能性癌基因。本研究构建了一个涉及 FOXP4-AS1 的调控网络,以更好地了解其在肝细胞癌 (HCC) 中的功能。方法 FOXP4-AS1 通过定量实时 PCR 在 HCC 和邻近的正常(对照)肝脏样本中进行评估。预测了差异表达的微小 RNA (DEmiRNA)。他们的靶基因通过基因...
cells.FOXP4-AS1 suppressed the viability and abundance of CD8+T cells through USP10-mediated deubiquitination of PD-L1.#PD-L1 facilitated CD8+T cell apoptosis in EC.#Upregulated FOXP4-AS1 promoted EC tumor growth by inhibiting the viability and facilitating the cytotoxicity and exhaustion of ...
We found that lncRNA FOXP4-AS1 was upregulated, while miR-136-5p was low-expressed in C666-1 cells, as opposed to NP69. Knockdown of FOXP4-AS1 notably suppressed C666-1 cell growth, inhibited cell migration and invasion. We also observed that E-cadherin expression was fortified and N-...
Functionally, while FOXP4-AS1 downregulation inhibited proliferation, migration and invasion of MCL cells, FOXP4-AS1 overexpression had promotive effects on these cellular processes. Mechanistically, FOXP4-AS1 was found to act as a competing endogenous (ce)RNA for miR-423-5p to regulate the ...
FOXP4-AS1LSD1EZH2LATS1Osteosarcoma (OS) is the most common malignant bone tumor in children and adolescents. LncRNA has been confirmed to participate in a variety of cancers. The purpose of this study was to explore the effect of FOXP4-AS1 on the development of osteosarcoma (OS) and its ...
FOXP4-AS1Nasopharyngeal carcinomaBiomarkerThis study was performed to probe the clinical significance of serum lncRNA FOXP4-AS1 in nasopharyngeal carcinoma (NPC) tumorigenesis. LncRNA FOXP4-AS1 from nasopharyngeal carcinoma patients and healthy volunteers were abstracted and converged. Quantitative real-...