Mechanistically, FOXP4-AS1 mediates several cellular processes mainly through its target genes. Therefore, FOXP4-AS1 has been extensively investigated for its diagnostic, prognostic, and therapeutic potential. In this review, we discuss the expression patterns, major role...
Functionally, high FOXP4-AS1 level was associated with increased cell proliferation and decreased cell apoptosis, indicating that FOXP4-AS1 exerted oncogenic functions in the tumorigenesis of PCa. Furthermore, FOXP4-AS1 was located in the cytoplasm of PCa cell lines and positively regulated FOXP4. ...
Methods: In this work, levels of lncRNA forkhead box P4 antisense RNA 1 (FOXP4-AS1) in CC cell lines and normal cell lines were analyzed with quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) method. Effects of FOXP4-AS1 on CC cellular behaviors including pr...
FOXP4-AS1结直肠癌增殖特异性蛋白1(SP1)大量的证据表明,长链非编码RNAs (long non-coding RNAs)在结直肠癌发生发展中发挥重要作用.有迹象表明,lncRNA FOXP4-AS1推动结直肠癌的进程.本文通过数据库信息分析发现,FOXP4-AS1在结直肠癌中高表达且与患者较差的预后正相关.实时荧光定量PCR方法也证实,FOXP4-AS1在结直...
We found that lncRNA FOXP4-AS1 was upregulated, while miR-136-5p was low-expressed in C666-1 cells, as opposed to NP69. Knockdown of FOXP4-AS1 notably suppressed C666-1 cell growth, inhibited cell migration and invasion. We also observed that E-cadherin expression was fortified and N-...
Functionally, while FOXP4-AS1 downregulation inhibited proliferation, migration and invasion of MCL cells, FOXP4-AS1 overexpression had promotive effects on these cellular processes. Mechanistically, FOXP4-AS1 was found to act as a competing endogenous (ce)RNA for miR-423-5p to regulate the ...
Conclusion FOXP4-AS1 demonstrates a notable increase in expression in BUC, leading to a suppression of LATS2 expression through the recruitment of EZH2 to the promoter region of LATS2. This regulatory process ultimately influences the proliferation and migra...
FOXP4PI3K/AKT信号通路目的研究FOXP4-AS1在甲状腺乳头状癌(PTC)组织中表达水平及其与临床病理特征之间的关系;明确FOXP4-AS1在PTC中的具体生物学功能,并初步探究其可能的作用机制.方法(1)生物信息学筛选FOXP4-AS1和甲状腺癌预后的相关性:下载GEO数据库(GENE EXPRESSION OMNIBUS)的GSE66783数据集,并从癌症基因组图谱(...
FOXP4-AS1lncRNAproliferationTNM stageDespite improvements in diagnosis and treatment, colorectal cancer (CRC) remains the third most common malignancy, and fourth‐leading cause of cancer‐related death worldwide, and has a particularly high incidence in Western countries. Recent studies have suggested ...
In addition, FOXP4‐AS1 could upregulate the expression of FOXP4 by sponging miR‐3184‐5p. Finally, we found that Yin Yang 1 (YY1) is a transcription factor that can transcriptionally activate both FOXP4‐AS1 and FOXP4 in ESCC cells. In a word, YY1‐induced upregulation of FOXP4‐AS1...