FOXP4-AS1Nasopharyngeal carcinomaBiomarkerThis study was performed to probe the clinical significance of serum lncRNA FOXP4-AS1 in nasopharyngeal carcinoma (NPC) tumorigenesis. LncRNA FOXP4-AS1 from nasopharyngeal carcinoma patients and healthy volunteers were abstracted and converged. Quantitative real-...
Functionally, high FOXP4-AS1 level was associated with increased cell proliferation and decreased cell apoptosis, indicating that FOXP4-AS1 exerted oncogenic functions in the tumorigenesis of PCa. Furthermore, FOXP4-AS1 was located in the cytoplasm of PCa cell lines and positively regulated FOXP4. ...
通过细胞及动物实验,论证了FOXP4-AS1高表达对PCa的增殖促进能力: 为了研究FOXP4-AS1在PCa中的调控模式,通过FISH实验确认了FOXP4-AS1主要位于细胞质,因此,FOXP4-AS1应该是转录后调控。ceRNA是lncRNA的常见转录后调控模式, FOXP4-AS1是否具有miRNA结合能力呢?接下来,进行Ago2-RIP分析(Ago2是miRNA结合蛋白,Ago2能沉...
Methods: In this work, levels of lncRNA forkhead box P4 antisense RNA 1 (FOXP4-AS1) in CC cell lines and normal cell lines were analyzed with quantitative Real-Time Polymerase Chain Reaction (qRT-PCR) method. Effects of FOXP4-AS1 on CC cellular behaviors including pr...
[2]杨惠芳,汤蕊,罗雪,等.甲状腺乳头状癌细胞中长链非编码RNA FoxP4-AS1的表达及其生物学功能[J].中国普通外科杂志,2022,31(5):619-630. [3]何亚丽,毛玉娟,申进增,等.长链非编码RNA在甲状腺乳头状癌中的表达及功能分析[J].中国临床药理学杂志,2021,37(10):1209-1213. ...
MCM3AP-AS1 promoted the expression of miR-194-5p target gene forkhead box A1 (FOXA1) in HCC cells by binding to miR-194-5p. Moreover, MCM3AP-AS1 knockdown induced proliferation inhibition, G1 arrest and apoptosis of HCC cells [123]. CASC2 not only regulates EMT through miR-367/FBXW...
Non-coding RNAs do not encode proteins and regulate various oncological processes. They are also important potential cancer diagnostic and prognostic biomarkers. Bioinformatics and translation omics have begun to elucidate the roles and modes of action o
Exosomal miR-101-3p and miR-423-5p inhibit medulloblastoma tumorigenesis through targeting FOXP4 and EZH2. Cell Death Differ. 2022;29:82–95. https://doi.org/10.1038/s41418-021-00838-4. 15. Wang Q, Wang H, Yan H, Tian H, Wang Y, Yu W, et al. ...
Except for two lncRNA/mRNA pairs (Foxd2os/ Foxd2, F730043M19Rik/Atxn7l1), coding genes were up to 2800-fold higher expressed than their antisense lncRNAs (Supplementary Fig S1B). Using published microarray data for the C3(1) mouse model,24 we found Pcdh7, Gabrg3, and Hoxa11 ...
为了研究FOXP4-AS1在PCa中的调控模式,通过FISH实验确认了FOXP4-AS1主要位于细胞质,因此,FOXP4-AS1应该是转录后调控。ceRNA是lncRNA的常见转录后调控模式, FOXP4-AS1是否具有miRNA结合能力呢?接下来,进行Ago2-RIP分析(Ago2是miRNA结合蛋白,Ago2能沉淀下lncRNA,说明miRNA可以与lncRNA结合),发现FOXP4-AS1与FOXP4均...