Foxp3-DTR-EGFP小鼠是一种在免疫学研究中广泛使用的转基因小鼠模型,这些小鼠在Foxp3基因座上插入了白喉毒素受体(DTR)和增强型绿色荧光蛋白(EGFP)基因。这种设计使得研究人员能够通过注射白喉毒素(DT)特异性地去除表达Foxp3的调节性T细胞(Tregs),并通过EGFP追踪这些细胞。
将IRES-DTREGFP共表达结构插入到小鼠Foxp3基因终止密码子处。应用领域:DTR工具鼠 *使用本品系发表的文献需注明: Foxp3-IRES-DTRGFP mice (Cat. NO. NM-KI-190046) were purchased from Shanghai Model Organisms Center, Inc.. 验证数据 Fig1. Expression of GFP on Tregs in Blood and Spleen in Foxp3-IR...
将IRES-DTREGFP共表达结构插入到小鼠Foxp3基因终止密码子处。 应用领域:DTR工具鼠 *使用本品系发表的文献需注明: Foxp3-IRES-DTRGFP mice (Cat. NO. NM-KI-190046) were purchased from Shanghai Model Organisms Center, Inc.. 验证数据 Fig1. Expression of GFP on Tregs in Blood and Spleen in Foxp3-...
品系全名 LEW-Foxp3em1(IRES-DTREGFP-WPRE-pA)Smoc 目录号 NR-KI-232394 品系状态 活体 导出PDF 基因信息 基因名 Foxp3 基因曾用名 RGD1562112 染色体位置 X NCBI ID 317382 RGD ID 1562112 Ensembl ID ENSRNOG00000011702 Pubmed Foxp3 人类同源基因 ...
Given that glutamine is indispensable for T cell activation, we evaluated the effect of DON in the context of Treg depletion (Foxp3DTR mice). In the absence of Tregs, DON wasn't able to prevent inflammation, suggesting a Treg dependent effect. Plasma metabolomic profiling revealed that DON ...
Further, diphtheria toxin was used to ablate foxp3 + Tregs in foxp3 DTR mice after establishing an immune response. In this model, mice were immunized with sheep globulin in adjuvant, and sheep anti-mouse GBM globulin was injected after 4 days to initiate progressive histological and functional...
(B) Foxp3DTR mice (n = 5–6) induced for EAE and treated with DTx or with DTx + Dex as above were transferred with flow cytometry sorted tTreg cells (1 × 106 cells per recipient). (C–E) Foxp3DTR mice were immunized with MOG 35-55 (150 μg for C or 300 μg for D), tr...
(a) AD-Tg/Foxp3- DTR þ and non-DTR-expressing AD-Tg littermates (AD-Tg/Foxp3-DTR À ; AD-Tg control) were treated with DTx for 4 consecutive days. mRNA levels of icam1, cxcl10 and ccl2 in the CP of 6-month-old AD-Tg/Foxp3-DTR þ mice, 1 day after last injection ...
Foxp3-IRES-DTRGFP 品系名:C57BL/6Smoc-Foxp3em3(IRES-DTREGFP)Smoc 品系状态:活体 | 目录号:NM-KI-190046 Cd177-Flox/Foxp3-IRES-tdTomato-2A-Cre 品系名:C57BL/6Smoc-em1(flox)Foxp3em3(IRES-tdTomato-2A-iCre)Smoc 品系状态:在研 | 目录号:NM-CKO-234673你...
C57BL/6 (B6), B6.SJL-Ptprca Pepcb/BoyJ (Cd45.1 mice), B6.129P2(Cg)- Rorctm2Litt/J (Rorg À / À ), STOCK Il-17atm1.1(icre)Stck/J, B6.129 Â 1-Gt(ROSA)26- Sortm1(EYFP)cos/J, B6.129(Cg)-Foxp3tm3(DTR/GFP)Ayr/J (Foxp3GFP) and C57BL/ 6-Foxp3tm1Flv/J (...