且治疗后期患者易对放化疗产生抵抗,仍需不断探索头颈肿瘤新的诊断和治疗手段.目前大量研究证实长链非编码RNAs可通过多种方式参与头颈肿瘤的发生发展.其中长链非编码RNA FOXD2-AS1已被证实在多种恶性肿瘤中表达异常,本文总结了FOXD2-AS1在头颈肿瘤中的表达情况及其生物学功能,探索FOXD2-AS1在头颈肿瘤诊断及治疗中...
ＡＳ１ 在Ｕ２５１人胶质瘤细胞株和ＨＥＢ细胞中的表达水平。利用人工合成的ｓｈＲＮＡ在Ｕ２５１细胞中对ＦＯＸＤ２ ＡＳ１表达进行干扰，采用ＭＴＴ实验和Ｔｒａｎｓｗｅｌｌ实验评估Ｕ２５１细胞的增殖和侵袭能力。 结果 与正常脑组织相比，ＦＯＸＤ２ ＡＳ１在胶质瘤组 织中的表达显著上调（Ｐ＜０ ...
长链非编码RNA FOXD2-AS1调控骨肉瘤细胞增殖 长链非编码RNAFOXD2-AS1调控骨肉瘤细胞增殖
目的研究长链非编码RNA(lncRNA) FOXD2-AS1在骨肉瘤组织及细胞株中的表达及对细胞增殖,凋亡,侵袭和迁移的作用与机制.方法采用实时定量反转录聚合酶链反应(RT-qPCR)检测36例骨肉瘤组织与癌旁组织中FOXD2-AS1的表达...
Long non-coding RNAs (lncRNAs) FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1) are reported could function as tumor promoter in several cancers. However, its role in hemangioma was not reported to yet. Expression level of FOXD2-AS1 in hemangioma tissues
3B and C). The invasive ability for the OS (MG63, Saos-2) cells was inspected using the transwell assay, indicating the repressed invasion induced by the FOXD2-AS1 knockdown (Fig. 3D and E). Apoptosis of the OS (MG63, Saos-2) cells was inspected using flow cytometry showed that FOX...
死亡组患者癌组织中lncRNA FOXD2-AS1表达水平升高,miR-1913表达水平降低(t/P=6.973/<0.001、6.307/<0.001);TNM分期为Ⅲ+Ⅳ期、发生淋巴结转移、低分化程度的NSCLC患者癌组织lncRNA FOXD2-AS1高表达比例高于TNM分期为Ⅰ+Ⅱ期、未发生淋巴结转移、中/高分化程度的NSCLC患者(χ^(2)/P=5.962/0.015、5.104/...
选取lncR-FOXD2-AS1相对高表达的SK-MES-1作为敲低实验的研究对象,将SK-MES-1细胞按照转染处理的不同分为NC组(转染si-NC)和si-FOXD2-AS1组(转染si-FOXD2-AS1),转染后,RT-qPCR检测细胞中lncR-FOXD2-AS1、miR-145-5p表达,CCK-8法检测细胞增殖活性,Transwell实验检测细胞迁移、侵袭能力,Western blotting...
There are comments on PubPeer for publication: Silencing lncRNA FOXD2-AS1 inhibits proliferation, migration, invasion and drug resistance of drug-resistant glioma cells and promotes their apoptosis via microRNA-98-5p/CPEB4 axis (2019)
Background/Aims: The current study elucidated the role of a long non-coding RNA (lncRNA), FOXD2-AS1, in the pathogenesis of hepatocellular carcinoma (HCC) and tdoi:10.2139/ssrn.3324729Cheng, YangZhitao, DongMinhui, XuZhang, Minfeng