FOXD2-?AS1是"促癌基因",能促进前列腺癌细胞的侵袭和转移,?FOXD2-?AS1可通过上调miR-206表示对肿瘤细胞的侵袭和转移发挥抑制作用,可作为前列腺癌的治疗靶点.聂永莉梅雄陈辉贤王静中文科技期刊数据库(全文版)医药卫生
长链非编码RNA FOXD2-AS1调控骨肉瘤细胞增殖 长链非编码RNAFOXD2-AS1调控骨肉瘤细胞增殖
ＡＳ１ 在Ｕ２５１人胶质瘤细胞株和ＨＥＢ细胞中的表达水平。利用人工合成的ｓｈＲＮＡ在Ｕ２５１细胞中对ＦＯＸＤ２ ＡＳ１表达进行干扰，采用ＭＴＴ实验和Ｔｒａｎｓｗｅｌｌ实验评估Ｕ２５１细胞的增殖和侵袭能力。 结果 与正常脑组织相比，ＦＯＸＤ２ ＡＳ１在胶质瘤组 织中的表达显著上调（Ｐ＜０ ...
lncRNA FOXD2-AS1在胃癌组织中较癌旁组织明显增高,并与患者肿瘤分期及预后相关;lncRNA FOXD2-AS1在胃癌各细胞系中表达升高,抑制lncRNA FOXD2-AS1的表达明显降低胃癌细胞增殖、迁移及侵袭能力,并上调E-Cadherin的表达,下调N-cadherin、Vimentin、β-catenin及Cyclin-D1的表达(均P < 0.05)。 结论 lncRNA FOX...
3B and C). The invasive ability for the OS (MG63, Saos-2) cells was inspected using the transwell assay, indicating the repressed invasion induced by the FOXD2-AS1 knockdown (Fig. 3D and E). Apoptosis of the OS (MG63, Saos-2) cells was inspected using flow cytometry showed that FOX...
生存率高于miR-506-5p低表达者(χ2=18.485,P<0.05).结论 宫颈癌组织lncRNA FOXD2-AS1高表达、miR-506-5p低表达,二者表达呈负相关关系;早期检测宫颈癌组织lncRNA FOXD2-AS1、miR-506-5p表达可能有助于判断患者预后. 著录项
摘要: 目的:探讨lncRNA FOXD2-AS1 (FOXD2-AS1)通过调控miR-185-5p/CCND2分子轴参与胃癌细胞对阿帕替尼耐药性的分子机制.方法:收集无锡市第五医院2016年4月至2017年12月间收治的资料完整的25例胃癌患者癌组织和相应癌旁组织标本,采用qRT-PCR检测FOXD2-AS1、miR-18... 查看全部>> ...
Accumulating data indicate that long noncoding RNAs (lncRNAs) serve as important modulators in biological processes and are dysregulated in diverse tumors. The function of FOXD2-AS1 in gastric cancer (GC) progression and related biological mechanisms rem
There are comments on PubPeer for publication: Silencing lncRNA FOXD2-AS1 inhibits proliferation, migration, invasion and drug resistance of drug-resistant glioma cells and promotes their apoptosis via microRNA-98-5p/CPEB4 axis (2019)
LncRNA FOXD2 adjacent opposite strand RNA 1 (FOXD2-AS1), located on chromosome 1p33 and with a transcript length of 2527 nucleotides, is a novel cancer-related lncRNA. FOXD2-AS1 was recently found to exhibit aberrant expression in various malignancies, including gastric, lung, bladder, ...