Four‐Helix Bundle Motiffour-helix bundle motifThis article has no abstract. Keywords: four-helix bundle motifdoi:10.1002/047120918X.EMB0557Jennifer L. MartinJohn Wiley & Sons, Inc.
必应词典为您提供four-helixbundle的释义,网络释义: 四螺旋束;四螺旋捆绑;
In details, we show that both short subsequences composed only by polar residues and additional nonpolar residues inserted, via different point mutations in ad hoc positions, seem to play a significant role in stabilizing the fourhelix bundle conformation in the longer sequences. Finally, we ...
The stability of proteins is an important factor for industrial and medical applications. Improving protein stability is one of the main subjects in protein engineering. In a previous study, we improved the stability of a four-helix bundle dimeric de novo protein (WA20) by five mutations. The ...
They rely on cell-mediated and humoral reactions to overcome the pathoge…" [more]doi:10.1016/j.bbabio.2014.05.169JoanaP.CarrilhoCéliaV.RomoMiguelTeixeiraElsevier B.V.Biochimica et Biophysica Acta (BBA) - Bioenergetics
This hypothesis proposes that signals are transmittednthrough the four-helix bundle via changes in helix helix packing and that the helix packing changes in thenadaptation and protein interaction regions are tightly and antisymmetrically coupled. Specifically, strongnhelix packing in the adaptation region...
This polypeptide exists in solution mainly as dimer that likely maintains a four-helix bundle motif. Thermal unfolding experiments demonstrate that the protein is considerably more stable at elevated temperatures than is a homotetramer consisting of four non-covalently associated copies of a 21-residue...
Each Mce3R monomer comprises 21 α-helices (α1-α21) folded into an asymmetric TFR-like structure with a core asymmetric four-helix bundle. This complex has two nonidentical HTH motifs and a single ligand-binding domain. The two nonidentical HTHs from each TFR bind within the high-affinity...
The NMR structure of the murine DLC2 SAM domain reveals a variant fold that is similar to a four-helix bundle. BMC Struct Biol. 7:34.Kwan JJ, Donaldson LW. The NMR structure of the murine DLC2 SAM domain reveals a variant fold that is similar to a four-helix bundle. BMC Struct ...
We have established by secondary structure analysis, circular dichroism (CD), and small-angle X-ray scattering (SAXS) that the FerA domain isα-helical and globular in solution. We have also constructed 3D models of FerA, and we conclude that it is a new four-helix bundle fold. However, ...