A major challenge to personalized oncology is that driver mutations vary among cancer cells inhabiting the same tumor. Whether this reflects principally disparate patterns of Darwinian evolution in different tumor regions has remained unexplored1鈥 5. We mapped the prevalence of genetically distinct ...
Though many mutations in MITF, SOX10, and PAX3 genes associated with WS2A, PCWH, and WS1 have been identified respectively in different ethnic groups, there is little to no studies in Iranian populations; thus this study is the first report of a genetically diagnosed case of PCWH in Iranian...
In summary, our study provides further evidence for inherited susceptibility to ALL and support for subtype specificity at risk loci. The different subtypes of B-ALL presumably reflect the different aetiology and evolutionary trajectories of progenitor cells influenced by inherited variation. Our findings ...
However, shortened photoperiod, a lack of food and/or increased population density all lead to the clonal production of males that are genetically identical to their sisters and mothers [18]. First instar male juveniles are easily distinguished from the females [19]. During maturation, daphniids ...
If the mother decides to have multiple children, they will be more genetically similar than any siblings, but less similar than identical twins. Twiblings! Twins of different ages At the 2, 4 or 8 cell stage, the cells in an embryo can turn intoany tissue in the body or placenta. This...
Although genetically engineered human growth hormone (hGH) is now commercially available, native pituitary-derived hGH is still used by physicians in many ... M Pocchiari,S Peano,A Conz,... - 《Hormone Research in Paediatrics》 被引量: 91发表: 1991年 Basal and dopamine-inhibited prolactin se...
showed that modern dog breeds are “distinct genetic units” and assigned the dog breeds used in this study to genetically distinct “clusters”. Our objectives here were to assess conserved polymorphism in TERT, and to establish if they segregated according to the breeds or randomly. In order ...
The objective of the study was to design and evaluate a pot experiment for determining the effects of irrigation with diluted winery wastewater on different soils. Four pedogenetically different soils were included in the experiment, i.e., (i) alluvial sand containing 3.3% clay from Rawsonville,...
Besides being genetically closely related and sharing the known obesity locus on Chr3 [5], the two parental mouse lines differ extremely in their metabolic phenotype. The mouse line S1 showed clear features of the metabolic syndrome while S2 was also obese, but had normal glucose homeostasis ...
inflorescence type and seed color. Although theF.dibotrysand two cultivated species are genetically similar, they differ considerably in habit and gross morphology. Sometimes, the morphology of species in genus is hard to distinguish different species accurately. On the other hand, the PCA result ba...