Procedure for the formulation of a Drug, a Pharmaceutical composition obtainable by this process and the use of the same.A drug formulation process which comprises admixing carrier particles with a solution of drug in water in a quantity of 1-3 % by weight of solution to total mix and a ...
Formulation design of a highly hygroscopic drug (pyridostigmine bromide) for its hygroscopic character improvement and investiga- tion of in vitro/in vivo ... YT Huang,TR Tsai,CJ Cheng,... - 《Drug Development & Industrial Pharmacy》 被引量: 30发表: 2007年 Formulation design of a highly hyg...
Drug release from prepared formulations using HPMC was dependent on concentration of super-disintegrant and swelling polymer used in loading dose layer and also on amount of HPMC compressed on core tablet; in case of compritol 888 ATO containing tablets, drug release was dependent on amount of ...
Formulation has become one of the most overlooked parts of drug development, but it can be the difference between an effective medicinal product and a very expensive placebo. A successful robust medicinal product is the result of a controlled set of interactions between the API, excipients and p...
Assay of RP 69698, a Novel LTB4-Antagonist, in Plasma by HPLC and its Application for Characterizing Pharmacokinetics of the Drug in Dogs To support the preclinical development of RP 69698, a novel antagonist of LTB4, a high-performance liquid chromatographic (HPLC) procedure was developed fo.....
Formulation of the 5th Five-Year Drug Abuse Prevention Strategy and Police Action An extended-release opioid analgesic (OxyContin, OC) was reformulated with abuse-deterrent properties to deter abuse. This report examines changes in abuse... 内田,一彦 - 警察学論集 被引量: 0发表: 2018年 Change...
The properties of any drug are a composite of the innate activity and properties of the compound as modulated by the formulation in which it is to be presented. To optimise their clinical effectiveness, the design of these formulations is becoming an increasingly important part of the development...
The study of the absorption, distribution, metabolism, excretion and interactions of a drug. PEGylation The covalent binding of polyethylene glycol (PEG) to a protein. EPITOPE An alternative term for an antigenic determinant. These are particular chemical groups on a molecule that elicit a specific...
Self-emulsifying drug delivery systems (SEDDS) are mixtures of oils and surfactants, ideally isotropic, sometimes including cosolvents, which emulsify under conditions of gentle agitation, similar to those which would be encountered in the gastro-intestinal tract. Hydrophobic drugs can often be dissolved...
T Furubayashi,D Inoue,A Kamaguchi,Y Higashi,T Sakane 摘要: The aim of this research is to clarify the influence of the viscosity of the nasal formulation on in vivo nasal drug absorption and its mechanism using an in vitro Caco-2 system. The drug solution was made viscous by the ...