Poloxamer 407 microspheres for orotransmucosal drug delivery. Part I: Formulation, manufacturing and characterization[J] . B. Albertini,N. Passerini,M. Di Sabatino,D. Monti,S. Burgalassi,P. Chetoni,L. Rodriguez.International Journal of Pharmaceutics . 2010 (1)...
The two-part article aimed to investigate poloxamer 407-based microspheres as a novel platform for enhancing and controlling the delivery of atenolol across the oromucosal tissue. In the Part I of the work, atenolol-loaded poloxamers 407 microparticles were prepared by the solvent free spray congeal...
Poloxamer 188 variant for the formulation of biologics Surfactants are used in the biopharmaceutical industry to stabilize antibodies in biologic formulations. In our research, a hydrophobic variant of Poloxamer 188 has shown promise in the formulation of biologics, particularly when used w...
Poloxamer 407 microspheres for orotransmucosal drug delivery. Part I: Formulation, manufacturing and characterization The two-part article aimed to investigate poloxamer 407-based microspheres as a novel platform for enhancing and controlling the delivery of atenolol acros......
with a poorly soluble drug cinnarizine can lead to controlled-release profile over 50 hours as opposed to 5 hours from monoolein suspensions.24Ionic polymers incorporated in cubosomes will have direct impact on release profile of the drugs in a controlled manner. For instance, poloxamer 407...
Poloxamer 407-based intranasal thermoreversible gel of zolmitriptan-loaded nanoethosomes: Formulation, optimization, evaluation and permeation studies. J. Liposome... S Shelke,S Shahi,S Jalalpure,... - 《Journal of Liposome Research》 被引量: 13发表: 2016年 Trans-nasal zolmitriptan novasomes: in-...
of submicron emulsion.The mean particle size,D50,D99 and ζ potential were measured to characterize and evaluate the physical stability of each formulation before and after sterilization,and the storage tests were also studied.RESULTS The combination of poloxamer188 and medium chain triglyceride(MCT) ...
The use of polymeric nanomicelles is an attractive strategy for improving the corneal and conjunctival penetration of therapeutic drugs and peptides, for sustaining drug levels and for reducing systemic side effects14. The present study examined the use of polyvinyl caprolactam-polyvinyl acetate-polyethyl...
As part of future formulation development work, the effect of lower PS80 concentrations as well as other stabilizing excipients (e.g., sugars, polyols, poloxamers) on minimizing sIgA mAb aggregation should be evaluated. We also evaluated the stability of sIgA2 mAb in each of the three ...
Poloxamer 407 is a non-ionic, tri-block copolymer surfactant composed of polyethylene oxide and polypropylene oxide, used in several pharmaceutical formulations for topical and oral delivery, and was purchased from Caesar & Loretz GmbH (Hilden, Germany). Results and discussion Maltodextrin is a ...