Incorporating drug-loaded particles into poloxamer gels sustains drug release by creating multiple rate limiting release barriers. Chemical modification of poloxamers appears to be a promising strategy to obtain prolonged sustained release for parenteral application without compromising the rheological properties...
The two-part article aimed to investigate poloxamer 407-based microspheres as a novel platform for enhancing and controlling the delivery of atenolol across the oromucosal tissue. In the Part I of the work, atenolol-loaded poloxamers 407 microparticles were prepared by the solvent free spray congeal...
Poloxamer 188 variant for the formulation of biologics Surfactants are used in the biopharmaceutical industry to stabilize antibodies in biologic formulations. In our research, a hydrophobic variant of Poloxamer 188 has shown promise in the formulation of biologics, particularly when used wi...
Poloxamer 407-based intranasal thermoreversible gel of zolmitriptan-loaded nanoethosomes: Formulation, optimization, evaluation and permeation studies. J. Liposome... S Shelke,S Shahi,S Jalalpure,... - 《Journal of Liposome Research》 被引量: 12发表: 2016年 Trans-nasal zolmitriptan novasomes: in-...
The use of polymeric nanomicelles is an attractive strategy for improving the corneal and conjunctival penetration of therapeutic drugs and peptides, for sustaining drug levels and for reducing systemic side effects14. The present study examined the use of polyvinyl caprolactam-polyvinyl acetate-polyethyl...
Novel Drug Delivery Technologies Mo. Rahil G. Bhura& Aliasgar Shahiwala 1111Accesses 2Citations Abstract Poor water solubility of a drug is a tough and difficult task for researchers and pharmaceutical scientists during the formulation and development of dosage forms. Poor drug solubility often leads...
Novel drug delivery system for the vesicular delivery of drug by the niosomes Non-ionic surfactant vesicles (or niosomes) are now widely studied as alternates to liposomes. An increasing number of nonionic surfactant has been found to form vesicles, capable of entrapping hydrophilic and hydrophobic...
As part of future formulation development work, the effect of lower PS80 concentrations as well as other stabilizing excipients (e.g., sugars, polyols, poloxamers) on minimizing sIgA mAb aggregation should be evaluated. We also evaluated the stability of sIgA2 mAb in each of the three ...
Maltodextrin, which is obtained by partial hydrolysis of starch, is water soluble and could serve as hydrophilic carrier for the encapsulation of protein-based active pharmaceutical ingredients. We investigated three different commercial maltodextrins (Dextrose Equivalents (DE) 4.0–7.0, DE 13.0–17.0 an...
This study confirms that a poloxamer hydrogel-based dex formulation provides an effective method for a prolonged delivery, providing a more uniform distribution of drug in the inner ear. 展开 关键词: Cochlea Perilymph Round window Intratympanic drug delivery Dexamethasone ...