OF THE DISCLOSUREA composition of matter for promoting protein\nsynthesis and suppressing urea formation in the human body,\nthe invention may be therapeutically employed as a treatment\nfor renal disease, hepatic failure, and protein deficiency.\nThe several embodiments of the present composition of...
1A)32. In S. cerevisiae, however, the homolog of EngB, Mrx8, is important for translating COX1 transcript in cold-stress conditions33. In this study, we aim to elucidate the function of the human homolog of EngB, GTPBP8. We find that it localizes in mitochondria where it interacts ...
First, we performed ribosome display on a library of sybodies,7 to select for those that can bind the P1 sequence using a peptide encompassing the P1 region of α-syn. We then performed a multiparametric screening in which sybody candidates were ranked on the basis of their ability to bind...
During megakaryopoiesis, megakaryocytes (MKs) undergo cellular morphological changes with strong modification of membrane composition and lipid signaling. Here, we adopt a lipid-centric multiomics approach to create a quantitative map of the MK lipidome
This study explored the novel mechanism of Astragaloside IV (As) in treating sepsis and its application through a biomimetic nano-delivery system (As@ZM). Sepsis, a condition of organ dysfunction caused by an abnormal host response to infection, poses a
The human body frequently excretes waste in the form of urine. In the excretion process, our kidneys play a crucial role. Urine contains both organic and inorganic substances. Examples of organic substances in urine include urea, creatinine, and uric acid. Inorganic solutes include sodium, ...
Gram-negative bacteria, such as Proteus species, are able to hydrolyze urea, producing ammonium and carbon dioxide and increasing urine pH and bicarbonate content.19 The main biochemical effect is alkalinization of urine and high levels of struvite and calcium phosphate supersaturation, which ...
Zika virus (ZIKV) is unique among orthoflaviviruses in its vertical transmission capacity in humans, yet the underlying mechanisms remain incompletely understood. Here, we show that ZIKV induces tunneling nanotubes (TNTs) in placental trophoblasts which facilitate transfer of viral particles, proteins,...
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(A) Regions of 1H–15N SOFAST-HMQC spectra recorded during the folding of human β2m (in 10 mM sodium phosphate buffer pH 6.2, 25 °C, 0.8 M final urea concentration). Resonances for 93V, 69E and 96E are shown in a series of spectra recorded at 3, 4, 10, 20 min after folding ...