Treatments or medical conditions that would imply a modification of the melatonin metabolism including drug intake (fluvoxamine, 5- or 8-metoxypsoralen, cimetidine, carbamazepine and rifampin, analgesics), known liver abnormality or detected during the screening visit, or known autoimmune disease...
Biliary excretion is a major drug elimination pathway that affects their efficacy and safety. The currently available in vitro sandwich-cultured hepatocyte method is cumbersome because drugs accumulate in the closed bile canalicular lumen formed between hepatocytes and their amounts cannot be mealsured ...
Coacervation in polyzwitterion-polyelectrolyte systems and their potential applications for gastrointestinal drug delivery platforms. Nat. Commun. 13, 2250 (2022). Article ADS CAS PubMed PubMed Central Google Scholar Brangwynne, C. P., Tompa, P. & Pappu, R. V. Polymer physics of intracellular...
Various drugs have been used for the treatment of leishmaniasis, but they often have adverse effects on the body's organs. In this study, we aimed to explore the effects of one type of drug, Miltefosine (MIL), and its analogue or modifier, liposomal Milt
Epidermal growth factor receptor (EGFR) activating mutations play crucial roles in the tumorigenesis of human non-small cell lung cancer (NSCLC). The mechanism regarding how EGFR signaling regulates myeloid cell leukemia sequence 1 (Mcl-1) protein stability and ubiquitination remains undefined. Methods...
In recent years, the global prevalence of myopia has reached an unprecedented level, especially in East Asia. Multitude of studies has shown that the etiology of myopia is complex. Some researchers have suggested that oxidative stress (OS) may contri
products in the compact, unified form factor family. This enables integrators and developers [...] telit.com UC864-E-AUTO是一款完整的3.5G无线通讯模块,它与泰利特(Telit )紧 凑 型系 列 的G SM/GPRS和CDMA产 品 完全 兼容 ,从而便于集成方和开发方一次性设计出它们的应用项目,并利用世界上两大...
DU PG Application Form 2024 - Delhi University has commenced the DU PG 2024 mid entry window on July 11, on the official website. Check release date and how to fill the application form online.
Rhino crime syndicates operate multi-nationally and are known to be involved in other high-risk criminal activities such as drug and diamond smuggling, vehicle theft, armed robberies and ATM bombings. (Rademeyer, 2012:40) suggests that certain key individuals have relationships with organized crime ...
(GGH) on chromosome 8, will produce two distinct leukemia genotypes with opposite drug sensitivities [34]. Left side, bottom: theARID5Brs7090445-C risk allele is preferentially duplicated in HD blast cells [40]. Right side, top: the recombination of the immunoglobulin heavy chain (IGH) gene ...