CA Private InvestigatorLicense No. 28286 PI Services BACKGROUND CHECKS BUSINESS CONSULTING BUSINESS INVESTIGATIONS CHILD CUSTODY CLEAR A CRIMINAL RECORD CHILD ABUSE INVESTIGATION CHILD SUPPORT ENFORCEMENT CRIME SCENE INVESTIGATION CRIMINAL DEFENSE INVESTIGATION CYBER SECURITY DATA INVESTIGATIONS ...
Treatments or medical conditions that would imply a modification of the melatonin metabolism including drug intake (fluvoxamine, 5- or 8-metoxypsoralen, cimetidine, carbamazepine and rifampin, analgesics), known liver abnormality or detected during the screening visit, or known autoimmune disease...
Whether an innovator company was looking to out-license a gold molecule as a platinum package, an innovator company was looking to bring a drug to market with a strong patent landscape, or a generic company was looking to enter the market with IP for their molecule, the case studies ...
- 《Drug Safety》 被引量: 174发表: 2003年 The onset of sucrose accumulation in cold‐stored potato tubers is caused by an increased rate of sucrose synthesis and coincides with low levels of hexose... Article first published online: 28 APR 2006 Received 15 January 1996; received in revised...
Newman, A. & Wenslow, R. Solid form changes during drug development: good, bad, and ugly case studies.AAPS Open2, 2 (2016). ArticleGoogle Scholar Braun, D. E. et al. Inconvenient truths about solid form landscapes revealed in the polymorphs and hydrates of gandotinib.Cryst. Growth Des...
1This application complies with laws and regulations such as Drug Administration Law of The People’s Republic of China, Implementing Regulation of the Drug Administration Law of The People’s Republic of China, and Drug Registration Regulation; ②The content of application form,the submitted informat...
Under a Creative Commons license open accessHighlights Summary The antidiabetic drug phenformin displays potent anticancer activity in different tumors, but its mechanism of action remains elusive. Using Shh medulloblastoma as model, we show here that at clinically relevant concentrations, phenformin eli...
By a combination of structural, chemical and mechanistic studies here we show that the inhibition of D-alanine:D-alanine ligase by the antibiotic D-cycloserine proceeds via a distinct phosphorylated form of the drug. This mechanistic insight reveals a bimodal mechanism of action for a single ...
To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. Reprints and permissions About this article Cite this article Kern, C.C., Townsend, S., Salzmann, A. et al. C. elegans feed yolk to their young in a form of primitive lactation. Nat Commun 12, 5801...
NewDrugApplication(NDA)BiologicsLicenseApplication(BLA) (Selectone) AbbreviatedNewDrugApplication(ANDA) 17.IfanNDA,identifythetype18.IfaBLA,identifythetype 505(b)(1)505(b)(2)351(a)351(k) 19.Ifa351(k),identifythebiologicalreferenceproductthatisthebasisforthesubmission. ...