Such forces might result from direct pulling by the cell, or from shearing motion on the particles trapped between cell and substrate. Irrespective of its origin and direction, any physical force acting on the bond should increase its unfolding rate. Bell´s model makes this notion quantitative...
et al. Both contractile axial and lateral traction force dynamics drive amoeboid cell motility. J. Cell Biol. 204, 1045–1061 (2014). Article CAS PubMed PubMed Central Google Scholar Hur, S. S., Zhao, Y., Li, Y. S., Botvinick, E. & Chien, S. Live cells exert 3-dimensional ...
Reliability theory for receptor-ligand bond dissociation. Cell adhesion in the presence of hydrodynamic forces is a critical factor in inflammation, cancer metastasis, and blood clotting. A number of assays have r... Tees,FJ David,Woodward,... - 《Journal of Chemical Physics》 被引量: 52发表...
cell adhesionintegrin signalingsingle molecule biophysicsmolecular dynamics simulationsconformational changesTalin is an integrin-binding protein located at focal adhesion site and serves as both an adapter and a force transmitter. Its integrin binding activity is regulated by the intramolecular autoinhibition ...
formation and remains expressed in the heart until tadpole stage, at which point it is downregulated in the heart except in discrete patches of cardiac ... DD Brown,AC Davis,FL Conlon - 《Gene Expression Patterns》 被引量: 22发表: 2006年 Dynamics of a discrete chain of bi-stable elements...
We describe the enforced unbinding of a bead from i) a supported membrane, and ii) a cell surface. The force necessary to unbind the bead is obtained and is shown to be within the range accessible in micromechanical experiments. DOI: 10.1209/epl/i2002-00129-8 被引量: 40 年份: 2002...
Periodic organization of cells is required for the function of many organs and tissues. The development of such periodic patterns is typically associated with mechanisms based on intercellular signaling such as lateral inhibition and Turing patterning. H
Ultra-stable magnetic tweezers are used for measuring the conformational dynamics of individual proteins at physiologically relevant low forces and over long timescales. Magnetic fields are created by using either permanent magnets or a tape head, which generates precisely calibrated forces for pulling sin...
Hence, the present study aimed to develop a simple, versatile model based on Computational Fluid Dynamics (CFD) simulation. Current observations of CFD have shown the regions of modulated shear stress by the disturbed fluid flow. To execute and validate the model in real sense, cell morphology,...
Mechanical forces acting on ligand-engaged T-cell receptors (TCRs) have previously been implicated in T-cell antigen recognition, yet their magnitude, spread, and temporal behavior are still poorly defined. We here report a FRET-based sensor equipped either with a TCR-reactive single chain antibod...