For the past couple of weeks, the business here at DMG has been incredibly slow, both in-store and online. We know it is cold out there and somewhat depressing due to the ongoing bad news. Even the newsletter hasn’t generated near as much revenue as it usual...
Immune-checkpoint inhibitors (ICBs), in addition to targeting CTLA-4, PD-1, and PD-L1, novel targeting LAG-3 drugs have also been approved in clinical application. With the widespread use of the drug, we must deeply analyze the dilemma of the agents and
Among 300,000 species in angiosperms, Orchidaceae containing 30,000 species is one of the largest families. Almost every habitats on earth have orchid plants successfully colonized, and it indicates that orchids are among the plants with significant ecol
Among 300,000 species in angiosperms, Orchidaceae containing 30,000 species is one of the largest families. Almost every habitats on earth have orchid plants successfully colonized, and it indicates that orchids are among the plants with significant ecol
To clarify whether the JE is self-sustaining or replaced by the oral epithelium (or a combination of both), JE regeneration following gingivectomy (removal of the JE) has been studied and observed to occur for nearly 50 years [308,309] leading others to conclude regenerated JE is derived ...
2D materials are attractive for nanoelectronics due to their ultimate thickness dimension and unique physical properties. A wide variety of emerging spintronic device concepts will greatly benefit from the use of 2D materials, leading a better way to man
The most common symptoms are sleepiness, fatigue, and general malaise. Hepatomegaly, splenomegaly, ascites and occasional peripheral edema can be observed during physical examination. Because of the insidious onset, nearly 30% of AIH patients demonstrated histological cirrhosis at accession [4,55]. ...
BgsA is the glycosyltransferase (GT) involved in the synthesis of a linear mixed-linkage β-glucan (MLG), a recently described exopolysaccharide activated by c-di-GMP in Sinorhizobium meliloti and other Rhizobiales. Although BgsA displays sequence and structural homology with bacterial cellulose synthase...
1, biotech drugs (proteins, peptides and monoclonal antibodies) represent 31% of the novel NMEs, nearly approaching the number of single-target drugs (34%). This clearly reflects the recent increased pharma interest in discovery of biologics [7], which build on the premise of a personalized ...