Therefore, the effect of mutation could be due to steric hindrance caused by the Phe moiety preventing the interaction of the agonist with His137. To test this idea further, we performed a conformational search on the GPR40 model in complex with GW9508. In the L186F mutant, we observed ...
Indeed, the idea that cancer formation and progression can be considered an evolutionary process was first theorised in 1976 [10], a theory which has since been validated using modern genomics approaches. Tumourigenesis has traditionally been thought to occur in a multistage step-wise fashion by ...