合成叶酸(Folic Acid)会掩盖维生素B12的缺乏,耐受上限为1mg/天,且大剂量可能会增加癌症风险; 2017年营养学界权威杂志《American Journal of Clinical Nutrition》(影响因子:6.504)发表了一篇《Total folate and unmetabolized folic acid in the breast milk of a cro...
合成叶酸(Folic Acid)会掩盖维生素B12的缺乏,耐受上限为1mg/天,且大剂量可能会增加癌症风险; 2017年营养学界权威杂志《American Journal of Clinical Nutrition》(影响因子:6.504)发表了一篇《Total folate and unmetabolized folic acid in the breast milk of a cross-section of Canadian women》②文章,对加拿大妇...
[6]. Anderson CA, Beresford SA, McLerran D, Lampe JW, Deeb S, Feng Z, Motulsky AG. Response of serum and red blood cell folate concentrations to folic acid supplementation depends on methylenetetrahydrofolate reductase C677T genotype: results from a crossover trial. Mol Nutr Food Res. 201...
Folate is the anionic form of folic acid. At physiological pH the acid-base form is folate. Very often, the term “folic acid” refers to the fully oxidized synthetic compound used in dietary supplements, whereas “folate” refers to the various tetrahydrofolate derivatives naturally present in ...
[3]. Lillycrop KA, et al. Dietary protein restriction of pregnant rats induces and folic acid supplementation prevents epigenetic modification of hepatic gene expression in the offspring. J Nutr. 2005 Jun;135(6):1382-6. [4]. Pietrzik K, et al. Folic acid and L-5-methyltetrahydrofolate:...
Conversion of this product to tetrahydrofolate occurs in both, apicomplexans and their mammalian hosts, by the action of dihydrofolate reductase but the homologous enzyme involved in this reaction can differ remarkably in its properties. In addition to the ability of ...Encyclopedia of Parasitology...
On the other hand, folic acid, the supplement form ofVitamin B9, remains metabolically inactive until it is converted into folates. The conversion of folic acid to folates occurs in your liver. First, enzyme dihydrofolate reductase converts folic acid to tetrahydrofolate, THF. ...
Dietary folates are stated to have about half the bioavailability of crystalline folic acid. The naturally occurring folate polyglutamates are largely deconjugated, and then re- duced by dihydrofolate reductase in the intestines to form 5-methyltetrahydrofolate, which appears in the portal ...
Folic acid antagonists Previously, folic acid antagonists, which are known to be highly embryolethal, were used in clinical trials as abortifacients (agents causing abortion). Although three-fourths of the pregnancies were terminated, almost one-fourth of the embryos that survived to term were ...
Definition (NCI_CRCH)Synthetic folate in fortified foods and supplements containing a single glutamate molecule. Definition (NCI)A collective term for pteroylglutamic acids and their oligoglutamic acid conjugates. As a natural water-soluble substance, folic acid is involved in carbon transfer reactions...