Folic acid stimulates hematogenic functions in the organism. In animal and plant tissues it takes part—in reduced form, that is, in the form of tetrahydrofolic acid and its derivatives—in the synthesis of purine and pyrimidine bases, certain amino acids (se-rine, methionine, histidine), choli...
Thymidylate synthase is required for the synthesis of DNA. Folic acid can be synthesized by bacteria, but not animals. Drugs that inhibit H2 folate reductase, or thymidylate synthase, are effective anticancer agents. The megaloblastic anemia associated with vitamin B12 deficiency can be partially ...
Folate derivatives (FDs) are important cellular cofactors in the synthesis of nucleotides required for DNA replication, in the synthesis of the amino acids glycine and methionine and in the metabolism of histidine, glutamic acid and serine. These factors are also required for the initiation of prote...
Folic acid, water-soluble vitamin of the B complex that is essential in animals and plants for the synthesis of nucleic acids. Folic acid was isolated from liver cells in 1943. The vitamin has a wide variety of sources in the human diet, including leafy
Intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by dihydrofolate reductase (DHFR). In bacteria, dihydrofolic acid is generated from 7,8-dihydropteroate by dihydrofolate synthetase. Description Intermediate in mammalian conversion of dietary folic acid to tetrahydrofolate by ...
Various materials such as citric acid, urea, glycerol, amino acids, and polyamines are employed in carbon dots synthesis via water pyrolysis or microwave radiation methods. The optical and fluorescent properties of carbon dots are significantly influenced by the choice of precursors, given their ...
leading to a stronger signal in the XRD spectrum. Besides, the higher Crystallinity Index (CrI) in NCC (66.6%) compared to MCC (61.4%) is a consequence of the acid hydrolysis process in NCC synthesis. This process selectively removes amorphous regions, leading to a more crystalline structure ...
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Nasim MovagharnezhadDepartment of Organic ChemistryPeyman Najafi MoghadamDepartment of Organic ChemistryStarch - StrkeMovagharnezhad, N.; Moghadam, P.N. Folic acid linked amino-cellulose for in vitro evaluation of doxorubicin delivery: Synthesis and characterization. Starch-Starke 2016, 68, 92-99. ...
Sulfonamides and trimethoprim target thefolic acidbiochemical pathway of bacteria. These antibacterial compounds are termed folic acid pathway inhibitors. Sulfonamides interfere with the formation of folic acid, an essential precursor for nucleic acid synthesis. The synthetic pyrimidine derivative, trimethoprim...