Sulfonamides and trimethoprim target thefolic acidbiochemical pathway of bacteria. These antibacterial compounds are termed folic acid pathway inhibitors. Sulfonamides interfere with the formation of folic acid, an essential precursor for nucleic acid synthesis. The synthetic pyrimidine derivative, trimethoprim...
Previously, folic acid antagonists, which are known to be highly embryolethal, were used in clinical trials as abortifacients (agents causing abortion). Although three-fourths of the pregnancies were terminated, almost one-fourth of the embryos that survived to term were severely malformed. A ...
Via breakdown to PABA-glu, folic acid increasesE. colifolate synthesis. This pathway restores folate synthesis in a bacterial mutant defective in PABA synthesis, reversing the ability of this mutant to increaseC. eleganslifespan. Folic acid supplementation inC. elegansoccurs chiefly indirectly via ...
However, using folic acid and CBD, in combination, brings about adverse side effects. Experts advise people, especially women who are pregnant or contemplating pregnancy, to consult with their doctor before starting to use folic acid or CBD. ...
In this regard, the present study aimed to synthesize and characterize a novel nano-system based on NCC, CTAB, and FA for targeted delivery of crocin to cancer cells. FRs are overexpressed on the surface of various cancer cells, including colorectal cancer cells, making folic acid an ideal ...
The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery The potential of the folic acid biosynthesis pathway as a target for the development of antibiotics has been acknowledged for many years and validated by t... A Bermingham,JP Derrick - 《Bio...
the folic acid deaminase secretion pathway must be5个回答 必须叶酸脱氨酶的分泌途径2013-05-23 12:21:38 回答:匿名 deaminase分泌途径的叶酸必须 2013-05-23 12:23:18 回答:匿名叶酸脱氨基霉分泌物路必须是 2013-05-23 12:24:58 回答:匿名
1. Tournefolic acid B attenuates amyloid beta protein-mediated toxicity by abrogating the calcium overload in mitochondria and retarding the caspase 8-truncated Bid-cytochrome c pathway in rat cortical neurons. [J] . Chi CW, Lin YL, Wang YH, European Journal of Pharmacology: An International ...
In the methanogenic bacteria such as Methanococcus volta and Methanobacterium formicicum, methanopterin, a structurally modified folic acid, functions in the same way folic acid does in other cells. The pterin portion of methanopterin is biosynthetically derived from 7,8-dihydro-6-(hydroxymethyl) pt...
This is the first report of possible direct stimulation of hormone-resistant prostate cancer or interference of docetaxel cytotoxicity of prostate cancer in a patient with biochemical relapse of prostatic-specific antigen. This observation is of clinical