We added two more genes (metF and folD) to this set to complete the folate cycle on the basis of KEGG pathway information. This selection of genes encompasses core folate metabolism, a set of reactions that interconvert various folate species and produce methionine, glycine, thymidine, and ...
Methods: Candidate genes were screened to construct folate metabolism scores by Cox regression analysis. Functional enrichment between high- and low-folate metabolism groups was explored by GO, KEGG, GSVA, and ssGSEA. EPIC, MCPcounter, and xCell were utilized to explore immune cell infiltration ...
Fig. 1: Overview of folate metabolism in bacteria and mammals and targets of SMX and TMP. Orange arrows are specific to bacteria. Blue arrows are pathways specific to mammals. Black arrows are common to both bacteria and mammals. Mammalian dihydrofolate reductase (mDHFR) is able to reduce foli...
eat-2 vs WT comparisons showed enrichment for glutamine and glutamate metabolism, purine metabolism, arginine, nicotinamide, and branched-chain amino acid metabolism. (Supplementary Fig. 1d–g and Supplementary Table 3). Several KEGG terms were shared by all genotypes, including d-glutamine and d-...
Changes in core metabolism have recently been identified as an important process by which bacteria can acquire antibiotic resistance. This is evidenced by the selection of mutations in core metabolism genes inEscherichia colithat lower metabolic activity and reduce antibiotic lethality5. Our discovery of...
Changes in translational accuracy of Escherichia coli when folate metabolism is perturbed. Microbios. 1994; 77(313):231-7. 10. Tiganos E, Herrington MB. Kasugamycin inhibition of nonsense suppression by thymine-requiring strains of Escherichia coliK12. Can J Microbiol. 1993; 39(4):448- 50. ...
KEGG enrichment analysis of differentially expressed genes and proteins showed that several pathways in addition to folate biosynthesis were likely indirectly involved in folate metabolism and content (e.g., glycine, serine, and threonine metabolism; purine metabolism; cysteine and methionine metabolism; ...
KEGG enrichment analysis of differentially expressed genes and proteins showed that several pathways in addition to folate biosynthesis were likely indirectly involved in folate metabolism and content (e.g., glycine, serine, and threonine metabolism; purine metabolism; cysteine and methionine metabolism; ...
expressed gene-derived piRNAs, embryonic development and metabolism related pathways and biological processes, which were consisted to the regulatory roles of paternal folate supplementations, were significantly affected by the differentially expressed gene-derived piRNAs based on the GO and KEGG analyses. ...
The enriched gut symbionts Bacteroides xylanisolvens, Bacteroides thetaiotaomicron, Bacteroides dorei, and Bacteroides uniformis by GMD contributed to the increased gut folate and the subsequent enhancement of folate-dependent one-carbon metabolisms that mediated the beneficial effects of GMD. Tests with ...