Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore.Wai Leong.TamGenome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore, Singapore. tamwl@gis.a-star.edu.sg.Nature Publishing Group UKNature metabolism...
Folate-mediated one carbon (1C) metabolism supports a series of processes that are essential for the cell. Through a number of interlinked reactions happening in the cytosol and mitochondria of the cell, folate metabolism contributes to de novo purine and thymidylate synthesis, to the methionine cy...
masseonct.iateWd etraindsemnteimfybrasneveermaloleTcuhl1e7s–oTnregIL-t1r7aAnsþdiFffoexrpen3tþiatcioenlls- that may be feasible targets to manipulate Treg cell-associated tumour immune surveillance, and complement programmed cell death protein 1 (PD1)-mediated control of T-cell activation....
Cerebral folate metabolism is one potential new and promising target. Folate is absorbed across the gut and transported to the whole body by folate receptor alpha (FOLR1 or FRα) which is the main transporter and carries folate across the choroid plexus into the cerebrospinal fluid (CSF) [6]...
Nutrients 2013, 5 2458 Keywords: folate cycle; methionine cycle; mathematical model; population model; NHANES 1. Introduction The folate and methionine cycles play critical roles in cell metabolism with profound consequences for health and disease. Defects in the enzymes or insufficiencies in the B...
However, PCFT is also expressed in many other tissues, including the brain, where it might export folates from acidified endosomes after FRα-mediated endocytosis.11 At least five distinct inherited disorders of folate transport and metabolism are presently known, all of which lead to generalized ...
Elevated homocysteine levels and low vitamin B12 and folate levels have been associated with deteriorated bone health. This systematic literature review with dose-response meta-analyses summarizes th...
tetrahydrofolatereductase(MTHFR)andotherenzymesthatuseriboflavin,cobalamin,orvitaminB6ascofactors.TheseBvitaminsareessentialforthere-methylationandtranssulfurationofhomocysteine,whichisanimportantintermediateinone-carbonmetabolism.WestudiedtheMTHFR677CrTpolymorphismandBvitaminsasmodulatorsofone-carbonmetabolismin10,601...
Following each infusion, a time-out period was imposed for 20 s, during which responding was recorded but had no programmed consequences. After the timeout period, the red house light once again turned on, and a new self-administration training session started. Rats were put pack into their...
The main factors involved in this increase have been the way women live today and what they eat and drink. In fact, the obesity pandemic that is sweeping across the planet is considered to be the main contributory feature. This review aims to introduce to a new a...