Objectives:Fmoc solid phase peptide synthesis principle was used to synthesize MP-2 and the anti - tuomr activity of MP-2 was checked.Methods:MP-2 was synthesized by PSSM -8 automatic peptide synthesiz- er,experimental factors were optimized by orthogonal experiment,peptide -resins were cleaved ...
In the years since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The basic problems at the time of publication of this earlier work have now...
This study explores the best conditions to circumvent such drawbacks and the findings are used to prepare a highly complex linear depsipeptide exclusively on solid phase. This approach opens the door to a general fully Fmoc‐based strategy for the synthesis of complex depsipeptides....
This optimal situation no longer exists during the assembly of a difficult peptide, where the normally accessible solid phase Martin Quibell and Tony Johnson reaction matrix becomes partially inaccessible during assembly. This situation arises suddenly, typically 6-12 residues into the synthesis, and ...
5) solid phase peptide synthesis 固相多肽合成 1. The application of microwave and ultrasonic as two fields enhancement techniques in solid phase peptide synthesis was reviewed. 综述了两种场强化技术——微波和超声波在固相多肽合成中的研究进展,重点介绍了它们的作用机理、在强化多肽合成中的应用及反应器...
M. O'SHEASussex Cent. Neurosci., Sch. Biol., Univ. Sussex, Brighton BN1 9QJ, UKJohn Wiley & Sons, Ltd.CheminformKowalczyk, C. and M. O'Shea, Solid-phase synthesis of neuropeptides by Fmoc strategies. Methods Mol Biol, 1997. 73: p. 41-8....
Eptifibatide is the receptor antagonist of platelet glycoprotein GPⅡb/Ⅲa,Clinical study showed that it has the advantage of potent effect.In the present work,a strategy for the synthesis and purification of Eptifibatide was presented.Eptifibatide has been synthesized by solid-phase method using the...
Peptide C-terminal thioesters are key intermediates in a variety of applications, most notably the recently developed native chemical ligation methods for the total chemical synthesis of proteins. So far they have been prepared only by the use of the least prevalent Boc/benzyl solid-phase method ...
5) solid phase peptide synthesis 固相多肽合成 1. The application of microwave and ultrasonic as two fields enhancement techniques in solid phase peptide synthesis was reviewed. 综述了两种场强化技术——微波和超声波在固相多肽合成中的研究进展,重点介绍了它们的作用机理、在强化多肽合成中的应用及反应器...
文档热度: 文档分类: 待分类 文档标签: FmocSolidPhasePeptidePraticalApproach 系统标签: fmocpraticalpeptidesynthesissolidphase Fmoc Solid Phase Peptide Synthesis_A Pratical Approach,,Fmoc,Solid,Phase,Peptide,Pratical,Approach 君,已阅读到文档的结尾了呢~~ ...