Int. J. Peptide Protein Res.46. 174- 180.Thompson PE, Keah HH, Gomme PT, Stanton PG, Hearn MT. Synthesis of peptide amides using Fmoc-based solid-phase procedures on 4-methylbenzhydrylamine resins. Int J Pept Protein Res. 1995 Aug;46(2):174-80....
In the years since the publication of Atherton and Sheppard's volume, the technique of Fmoc solid-phase peptide synthesis has matured considerably and is now the standard approach for the routine production of peptides. The basic problems at the time of publication of this earlier work have now...
5 Difficult peptides MARTIN QUIBELL and TONY JOHNSON 1. Introduction Solid phase peptide synthesis (SPPS), first proposed by R. B. Merrifield in 1962 (1), has evolved over three decades into a tremendously powerful method for the preparation of peptides and small proteins (2, 3). An ...
5) solid phase peptide synthesis 固相多肽合成 1. The application of microwave and ultrasonic as two fields enhancement techniques in solid phase peptide synthesis was reviewed. 综述了两种场强化技术——微波和超声波在固相多肽合成中的研究进展,重点介绍了它们的作用机理、在强化多肽合成中的应用及反应器...
文档热度: 文档分类: 待分类 文档标签: FmocSolidPhasePeptidePraticalApproach 系统标签: fmocpraticalpeptidesynthesissolidphase Fmoc Solid Phase Peptide Synthesis_A Pratical Approach,,Fmoc,Solid,Phase,Peptide,Pratical,Approach 君,已阅读到文档的结尾了呢~~ ...
We report the synthesis of an α-formylglycine building block suitable for Fmoc-based solid-phase peptide synthesis. The building block was incorporated into a synthetic peptide derived from the active site of a Mycobacterium tuberculosis sulfatase....
continuous flow solid phase peptide synthesisnitrile formationtryptophan modificationTo investigate side reactions during the activation of side chain unprotected asparagine in Fmoc-solid phase peptide synthesis the peptide Met-Lys-Asn-Val-Pro-Glu-Pro-Ser was synthesized using different coupling conditions ...
5、behrendt r等(advances in fmoc solid-phase peptide synthesis [j]. journal of peptide science. 2016, 22, 4-27.)报道,目前已有上百个氨基、羧基及羟基的保护基团可用于多肽的合成,但能够满足在最终裂解时多肽羧基(cooh)末端可直接酰胺化(conh2)的保护基团却主要局限于spps。以经过特殊修饰的固相多肽合成...
摘㊀要:在基金科研成果的基础上ꎬ利用固相合成技术ꎬ设计了以９￣芴甲氧羰基(Ｆｍｏｃ)固相多肽合 成Ｓ１肽序的创新实验项目.实验采用简单易得和安全性更高的试剂ꎬ并使用高效液相色谱和质谱对合成的粗品进行纯度检测和结构确证ꎬ形成了对活性多肽合成和表征的一套完整的科研训练过程ꎬ对于激发学生的科研...
Synthesis of peptide α-thioesters Disclosed herein is a new method for the solid phase peptide synthesis (SPPS) of C-terminal peptide α thioesters using Fmoc/t-Bu chemistry. This method is based on the use of an aryl hydrazine linker, which is totally stable to conditio... JA Camarero,...