In a report that included 234 fluoxetine overdose cases, it was concluded that symptoms resulting from fluoxetine overdose were generally minor and short in duration.5 The most common overdose adverse effects included drowsiness, tremor, tachycardia, nausea and vomiting, and providing the patient with...
Indicated in combination with olanzapine for treatment of resistant depression (MMD in patients who do not respond to 2 separate trials of different antidepressants of adequate dose and duration in the current episode) Initial: 20 mg fluoxetine plus 5 mg olanzapine PO qHS Make dosage adjustments,...
Synopsis: Fluoxetine1is a new antidepressant which enhances serotoninergic neurotransmission through potent and selective inhibition of neuronal reuptake of serotonin. Metabolism by N-desmethylation occurs in man yielding desmethylfluoxetine, which also inhibits serotonin reuptake. Both the parent compound and ...
of SERT together with a longer duration of action than the S-(–)-isomer. However, the S-(–)-norfluoxetine metabolite is seven times more potent as an inhibitor of the 5-HT transporter than the R-(+)-metabolite, with a selectivity ratio approximately equivalent to that of S-fluoxetine....
of its precursor 5α-DHP. Moreover, the administration ofallopregnanolonedose-dependently reduced the duration of immobility in the FST (Khisti et al., 2000). The same authors presented findings suggesting that the antidepressant-like effects of fluoxetine but not imipramine in the FST were ...
In humans,exenatidereduces fasting and postprandialglucose levels, slows gastric emptying, and decreases food intake by 19%.155Theside effectsof exenatide in humans areheadache, nausea, and vomiting that are lessened by gradual dose escalation. Several clinical trials of 30 weeks’ duration have been...
The risk of developing tardive dyskinesia and the likelihood that it will become irreversible are believed to increase as the duration of treatment and the total cumulative dose of antipsychotic drugs administered to the patient increase; however, the syndrome can develop, although much less commonly,...
The experiment contained two parts with a total duration of 6 weeks (Figure 4). During the first 3 weeks of the experiment, rats were housed under the aforementioned conditions without additional experimental procedures. During the second 3 weeks, half of Controls and CSIS rats were ...
Treatment resistant depression (Major Depressive Disorder in patients, who do not respond to 2 separate trials of different antidepressants of adequate dose and duration in the current episode). PROZAC monotherapy is not indicated for the treatment of depressive episodes associated with Bipolar I Disorde...
QT interval of the electrocardiogram (ECG) is a measure of the duration of the ventricular depolarization and repolarization. In humans, prolongation of the QT interval is a known clinical risk factor for the development of ventricular arrhythmias including ‘Torsades de Pointes’ and possible sudden...