andM.SangeleerandG.BussiosandM.SDOSEuropean NeuropsychopharmacologyMesters, P., Sangeleer, M., Bussios, G., Bourgeois, M. (1995) Onset of action of fluoxetine 20 mg (Prozac) among ambulatory patients suffering from depressive disorders. European Neuropsychopharmacology, 5: 291...
Fluoxetine is well absorbed after oral administration, with mean peak plasma concentrations (Cmax) of 15 to 55 μg/L after a single oral dose of 30 or 40mg. Time to Cmax(tmax) is 6 to 8 hours; coadministration with food increases tmaxby 3 to 5 hours, but the extent of absorption and...
Three basic improvements in antidepressant therapy; faster onset of action, improved efficacy in refractory patients, and an improved side-effect profile, remain t... DA Evrard,BL Harrison - 《Annual Reports in Medicinal Chemistry》 被引量: 40发表: 1999年 Immunomodulatory effects of fluoxetine. A...
Fluoxetine is a bicyclic monoamine whose primary pharmacological action is selective inhibition of serotonin (5-hydroxytryptamine; 5-HT) reuptake; this action appears to be necessary for, but does not fully explain, its efficacy in the treatment of obsessive-compulsive disorder (OCD). It inhibits th...
A randomized, double-blind, and placebo-controlled trial of quetiapine augmentation of fluoxetine in major depressive disorder. The objective of this study was to investigate whether quetiapine, when compared with placebo, can speed the onset of action and improve the quality of res... A Garakani...
In line with these guidelines, studies have shown that whereas olanzapine was effective in short term bipolar depression, the combination with fluoxetine was superior especially with respect to onset of action and remission rate (Tohen et al., 2003; McIntyre et al., 2013). The olanza...
Unfortunately, informa- tion regarding the onset of action and time course of SRI-induced sexual side effects in women is scarce. However, recent studies suggest that both reduced li- bido and anorgasmia may display a relatively short on- set of action (р14 days) (Wikander et al. in ...
When evaluating changes in sexual function, obtaining a detailed history (including timing of symptom onset) is important because sexual symptoms may have other causes, including underlying psychiatric disorder Discuss potential management strategies to support patients in making informed decisions about treat...
Early onset of selective serotonin reuptake inhibitor antidepressant action: systematic review and meta-analysis. Arch Gen Psychiatry 63: 1217–1223. Fluoxetine, behavioral depression and ACh in NAc DT Chau et al Thiel CM, Huston JP, Schwarting RK (1998). Cholinergic activation in frontal cortex ...
for each new cycle, fluoxetine should be started 14 days before the onset of menstruation and continued until the first full day of menstruation. treatment may be continued for 6 months; benefit should then be reassessed before continuing further. a lower or less frequent dosage is recommended ...