HFS is generally observed after 8-9 weeks of fluorouracil administration but may occur earlier. Institute supportive measures for symptomatic relief of HFS. Withhold fluorouracil administration for Grade 2 or 3 HFS; resume fluorouracil at a reduced dose when HFS is completely resolved or decreased in...
Fluorouracil administered parenterally has been shown to be teratogenic in mice, rats, and hamsters when given at doses equivalent to the usual human intravenous dose; however, the amount of fluorouracil absorbed systemically after topical administration to actinic keratoses is minimal (see CLINICAL ...
Animal reproduction studies have not been conducted with fluorouracil. Fluorouracil administered parenterally has been shown to be teratogenic in mice, rats, and hamsters when given at doses equivalent to the usual human intravenous dose; however, the amount of fluorouracil absorbed systemically after t...
The face was then challenged with 5-FU for 2 weeks to determine whether the actinic keratoses had been eradicated. RESULTS: After 6 months of topical tretinoin therapy, biopsies revealed complete clearing of subclinical actinic keratoses. Challenge with 5-FU produced no inflammatory responses. ...
1990. Prolonged thrombocytosis in mice after 5-fluorouracil results from failure to down-regulate megakaryocyte concentration. An experimental model that ... PJ Chenaille,SA Steward,RA Ashmun,... - 《Blood》 被引量: 44发表: 1990年 Systemic hematologic effects of PEG-rHuMGDF-induced megakaryocyte ...
possibly is related to the dose, occur at any time of the treatment process (often a few months later). After Cerebellar signs in the withdrawal can be last for a few of weeks. Myocardial ischemia occasionally appeared in the 5-FU intravenous drip. The drug in animals is caused by abnorma...
The aim of the present study was to evaluate the clinical activity and side effects of a combination chemotherapy consisting of a five-day continuous infus
(length * width2) 2−1, where length was the longest and width was the shortest axis of the tumor. The mice were euthanized after 3 weeks of FU-based chemotherapy administration following the standard protocol. The xenografts were subsequently transplanted from mouse to mouse or frozen as ...
-Duration of therapy: Apply for up to 4 weeks as tolerated; continued treatment up to 4 weeks results in greater lesion reduction; local irritation is not markedly increased by extending treatment from 2 to 4 weeks, and is generally resolved within 2 weeks of cessation of therapy1%, 2%, 5%...
Results:Both treatments reduced the number of visible AK by 75% and produced equivalent reductions in keratinocyte atypia, hyperkeratosis, parakeratosis, and inflammation, with no significant alteration of preexisting solar elastosis and telangiectasia. Except for erythema that lasted 3 months in one pat...