• Females of reproductive potential and males with female partners of reproductive potential to use effective contraception during treatment with fluorouracil and for up to 3 months after the last dose of fluorouracil. Instruct female patients to contact their healthcare provider if they become pregna...
Hendrikvan den Berg, ...Jos H.Beijnen, inCancer Treatment Reviews, 2012 5-Fluorouracil After intravenous administration 5-fluorouracilrapidly penetrates the extracellular space and the cerebrospinal fluid. The volume of distribution exceeds slightly extracellular fluid space. Fluorouracil is in the cell ...
In an additional study, negligible amounts of labeled material were found in plasma, urine, and expired CO 2after 3 days of treatment with topically applied 14C-labeled fluorouracil. Indications and Usage for Fluorouracil Cream Fluorouracil Cream USP is recommended for the topical treatment of ...
the beginning of each cycle. Sterile filtered PBS alone was used as the vehicle control. Each cycle consisted of 5 consecutive days of injections followed by 9days of recovery. The treatment period lasted for 5weeks and mice were sacrificed 24 hr after the final injection of the third cycle....
To evaluate SN-38 absorption from the intestine, SN-38 was loaded in to the intestine on day 4 after 5-FU treatment. Pretreatment with 5-FU significantly increased SN-38 concentration in the blood 30, 60 and 90 min after SN-38 administration. The area under the curve for SN-38 in the...
The dose of Efudex topical is to apply a small amount of the cream to the area that is to be treated, once or twice daily after cleansing. Treatment lasts 2-6 weeks depending on the condition being treated. Wash hands immediately afterward. Do not use other prescription or over-the-counte...
Keloids are benign, fibroproliferative dermal tumours, often arising after trauma, that are more common in darker skin types. Numerous therapeutic options have been employed for the treatment of keloids; however, there is no one gold standard approach. Five-fluorouracil, a potent chemotherapeutic ...
Nature Reviews Cancer3,330–338 (2003)Cite this article 79kAccesses 3948Citations 35Altmetric Metrics Key Points The fluoropyrimidine 5-fluorouracil (5-FU) is an antimetabolite drug that is widely used for the treatment of cancer, particularly for colorectal cancer. ...
Erick Gamelin, Michele Boisdron-Celle - 《Critical Reviews in Oncology/hematology》 被引量: 121发表: 1999年 Dose monitoring of 5-fluorouracil in patients with colorectal or head and neck cancer-status of the art Dose monitoring of 5- uorouracil in patients with colorectal or head and neck can...
- 《Cancer Treatment Reviews》 被引量: 127发表: 2013年 Alternative Treatment Options in Colorectal Cancer Patients With 5–Fluorouracil- or Capecitabine-Induced Cardiotoxicity Most chemotherapy regimens in colorectal cancer treatment are 5-fluorouracil (5-FU)/leucovorin or capecitabine-based. Cardiotoxicity...