有腐蚀性。 一个强有力的抗肿瘤试剂,通过抑制胸苷酸合成酶,影响嘧啶合成从而消耗细胞内dTTP池,5- FU被代谢成核糖核苷酸和脱氧核糖核苷酸,并被注入到RNA和DNA。用5- FU处理细胞可导致细胞在S期积聚,5- FU已被证明可诱导p53依赖的细胞凋亡。 核酸代谢,研究稻、麦穗子分化,遗传代谢测定,植物生长发育研究。
F476739-10g 10g期货 现价:¥2,380.90 +- 大包装询价添加到收藏夹比较SDS中文版DATASHEET Skip to the end of the images gallery Skip to the beginning of the images gallery 基本描述 英文别名5-Fluorouracil | fluorouracil | 51-21-8 | 5-FU | Fluoroplex | Efudex | Adrucil | Carac | Fluracil...
5-Fluorouracil (5-FU) is an essential component of systemic chemotherapy for colorectal cancer (CRC) in the palliative and adjuvant settings. Over the past four decades, several modulation strategies including the implementation of 5-FU-based combination regimens and 5-FU pro-drugs have been ...
Notwithstanding recent treatment advances in metastatic colorectal cancer (mCRC), chemotherapy with a combination of a fluoropyrimidine and a folate agent, often 5-fluorouracil (5-FU) and leucovorin, remains the backbone of treatment regimens for the majority of patients with mCRC. This is despite ...
5-FU, 5-fluorouracilCAD, coronary artery diseaseCTA, computed tomography angiogramCV, cardiovascularFLOX, bolus dosing 5 fluorouracil, leucovirin, oxaliplatinFOLFOX, continuous infusion 5 fluorouracil, leucovorin, oxaliplatincardiotoxicitycoronary vasospasmfluoropyrimidine...
This study was designed to investigate the influence of TSER and MTHFR polymorphisms on the clinical outcomes of patients with colorectal cancer receiving 5-FU-based chemotherapy. Genomic DNA was isolated from 103 frozen or paraffin-embedded tissues of colorectal cancer patients. The genotypes of two...
The choice of fluoropyrimidine (either 5-fluorouracil (5FU) or capecitabine) was decided by the treating physician and patient before randomisation. Toxicity data were collected from all patients. Two hundred and three patients received 5FU plus oxaliplatin (OxMdG, 25%), 333 oxaliplatin+capecitabine...
Noninvasive Studies of FluoropyrimidinesFluoropyrimidines occupy a unique niche in the noninvasive studies of drugs. For one, 5fluorouracil (5-FU), which was introduced by Heidelberger in the late 1950s as an anticancer agent, continues to......
5-FUanginaarrhythmiabreast cancercapecitabinecardiotoxicitycolon cancerfluoropyrimidinesmyocardial infarctionpancreatic cancerBACKGROUND: The syndrome of 5-fluorouracil (5-FU)-associated cardiotoxicity remains poorly defined. PATIENTS AND METHODS: We performed a literature review (1969 - 2007) and compiled data...
5-FU is generated preferentially in tumor by exploiting the higher activity of thymidine phosphorylase in tumor tissue compared with normal tissue. Results of a randomized, phase II trial led to the selection of a regimen of capecitabine for further clinical development (1,250 mg/m twice daily ...