Fluid transport in the brain. Physiol. Rev. 102, 1025–1151 (2022). Article CAS PubMed Google Scholar Lei, Y., Han, H., Yuan, F., Javeed, A. & Zhao, Y. The brain interstitial system: anatomy, modeling, in vivo measurement, and applications. Prog. Neurobiol. 157, 230–246 (...
TransportA carpet of ependymal motile cilia lines the brain ventricular system, forming a network of flow channels and barriers that pattern cerebrospinal fluid (CSF) flow at the surface. This CSF transport system is evolutionary conserved, but its physiological function remains unknown. Here we ...
Drug transport in brain via the cerebrospinal fluid. Fluids Barriers CNS 2011; 8: 7.Pardridge WM (2011) Drug transport in brain via the cerebro- spinal fluid. Fluids Barriers CNS 8:17W. M. Pardridge, "Drug transport in brain via the cerebrospinal fluid," Fluids and Barriers of the CNS...
Transport of biochemical substances and other species in the cerebrospinal fluid is influenced by the latter's pulsatile flow. By combining magnetic resonance imaging and computational fluid dynamics, the cerebrospinal fluid flow field c... V Kurtcuoglu - 《Neurology Psychiatry & Brain Research》 被...
Perivascular spaces are important highways for fluid and solute transport in the brain enabling efficient waste clearance during sleep. However, the underlying mechanisms augmenting perivascular flow in sleep are unknown. Using two-photon imaging of naturally sleeping male mice we demonstrate sleep cycle-...
Methods for determining the permeability of the blood-brain barrier are described. The book also explores amino acid transport mechanisms in the choroid plexus, distribution of hormones by CSF, and the physiological aspects of lactate and peptides in the CSF. Special consideration is given to the ...
Aquaporins are intrinsic membrane proteins involved in water transport in fluid-transporting tissues. In the brain, aquaporin-4 (AQP4) is expressed widely ... DK Binder,X Yao,AS Verkman,... - 《Neuroreport》 被引量: 380发表: 2006年 Role of water channels in fluid transport studied by phenot...
Disturbances in this transport pathway could influence the drainage of amyloid β and other waste products, which may be relevant for the pathophysiology of Alzheimer's disease. 展开 关键词: Interstitial fluid Cerebrospinal fluid Ventricular system Paravascular space Glymphatic pathway ...
It is now evident, however, that circulating nutrients are provided to the CNS principally via transport across the BBB endothelium, and that CSF, in fact, is a relatively ineffective vehicle for solute delivery to many brain areas. Moreover, brain ISF and CSF differ in their origin, nutrient...
The glymphatic system is a network of perivascular spaces that promotes movement of cerebrospinal fluid (CSF) into the brain and clearance of metabolic waste. This fluid transport system is supported by the water channel aquaporin-4 (AQP4) localized to v