flow cytometryHRM PCRNPM1Introduction Nucleophosmin 1 ( NPM1) mutation is one of the most frequent gene mutations in adult acute myeloid leukemia (AML), being detected in 35% of all cases and in up to 60% of patients with normal karyotype AML. AML with mutated NPM1 has distinct pathology...
Acute leukemias are a heterogeneous group of malignancies with varying clinical, morphologic, immunologic, and molecular characteristics. Many distinct typ... EG Weir,MJ Borowitz - 《Seminars in Hematology》 被引量: 212发表: 2001年 Flow Cytometry in the Diagnosis of Acute Leukemia Fifty cases of ...
Flow Cytometry to Estimate Leukemia Stem Cells in Primary Acute Myeloid Leukemia and in Patient-derived-xenografts, at Diagnosis and Follow Up. J. Vis. Exp. (133), e56976, doi:10.3791/56976 (2018). Download Citation Reprints and Permissions JoVE Privacy ...
et al. Flow cytometry CD45 gating for immunophenotyping of acute myeloid leukemia. Leukemia 11, 1878–1886 (1997). https://doi.org/10.1038/sj.leu.2400847 Download citation Received07 March 1997 Accepted01 August 1997 Issue Date01 November 1997 DOIhttps://doi.org/10.1038/sj.leu.2400847 ...
flow cytometry in the diagnosis and classification of acute myeloid leukemia and detection of minimal residual lesions, raising our concern about the deficiency from the perspective of immunophenotyping markers due to their high degree of cross reactivity and low specificity among M0-M7 types, and ...
Acute myeloid leukemia (AML) is a heterogeneous, and if not treated, fatal disease. It is the most common cause of leukemia-associated mortality in adults. Initially, AML is a disease of hematopoietic stem cells (HSC) characterized by arrest of differentiation, subsequent accumulation of leukemia...
Table 1 Mileposts in the development of acute promyelocytic leukemia flow cytometry Full size table All the arguments discussed lead us to what we are all interested in: where is APL flow cytometry going? Maybe many answers are possible, but we want to focus on three main goals: (i) a be...
Significance of CD71 expression by flow cytometry in diagnosis of acute leukemia. In this study we investigated the significance of CD71 (transferrin receptor 1, TfR-1) as a flow cytometric marker in the diagnosis of acute leukemia (AL)... Liu,Qian,Wang,... - 《Leukemia & Lymphoma》 被引...
Objective:To investigate the significance of immunophenotype in children's acute leukemia via flow cytometry. Methods:Immunophenotypes were detected by three-color flow cytometry(FCM) and CD45/SSC gating in 185 cases of acute leukemia (AL) and antigentic expressions were analysed.Results:The coinciden...
Cytochemical staining has been used in the diagnosis of acute leukemia for more than 20 years. The general availability of flow cytometers and an extensive panel of antibody reagents useful for characterizing blood cell lineage question the usefulness of continuing routine use of the cytochemical stain...