Splenic T-cells alloreactivity measured via mixed lymphocyte reactivity (MLR) assay and compared to that of T-cells from groin draining lymph nodes (DLN) Results In groups 2 and 3, systemic blood Fk506 levels were maintained at a constant therapeutic level between 5鈥 15 ng/ml for 146(C...
ToevaluatetherelationbetweenbloodleveloftacrolimusandAUCafterre— naltransplantation. Methods BloodassayofFK506wasconductedat0～12hafteroraladministration, thestudywascarriedoutin60renaltransplantationorpancreas—kidneytransplantationpatients.AUCwas computedaccordingtothebloodFK506levels.Regressionanalysiswasusedtostudythe...
Endotoxin Level: <1.0EU per 1μg (determined by the LAL method). Formulation: Supplied as lyophilized form in PBS, pH7.4, containing 5% sucrose, 0.01% sarcosyl. Predicted isoelectric point: 7.9 Predicted Molecular Mass: 13.2kDa Accurate Molecular Mass: 17kDa as determined by SDS-PAGE reducing...
Ascomycin level is less than 0.5%. FK-506 is a potent immunosuppressant and in vitro T cell proliferation blocker. It has been shown to disrupt calcineurin (also known as CaN or phosphatase 2B)-mediated signal transduction in T lymphocytes. The compound interacts with its FK506-binding protein...
The a verage blood sugar level(12.2±5.8mmol/L) and the incidence of PTDM(20%) in FK506 +MMF+Pred group were significantly higher than those of CsA treatment group. CONCLUSION The influence of FK506 on glucose metabolism is remarkable,and attention should be paid to the a ssociation ...
[2] Sewing KFr. Pharmacokinetics, dosing principles and blood level monitoring of FK506[J]. Transpl Proc, 1994;26(6): 3267-3269. 收稿日期:2000-01-12 修回日期:2000-03-05
Conclusio with that in M group, urinary protein excretion was significantly decreased and the level of serum ALB was significantly increased in FK506 group. Immunohistochemistry showed that the expressio of TGF β1 and NF κB were significantly lower in FK506 group than those in group M. The ...
patientswouldaffectthelevelofALP,GGT,Urea,AST,RBC,HB,WBC,LYMandNEU.However,ithadlittleeffectson thelevelsofCr,ALT,GLU,UAandMONO. Keywords:FK506;liverfunction;renalfunctionblood;routineexamination 他克莫司(tacrolimus,又称FK506),是一种 具有大环内酯结构的新型强效免疫抑制剂,其作用 机制是抑制多种细胞因...
Ascomycin level is less than 0.5%. FK-506 is a potent immunosuppressant and in vitro T cell proliferation blocker. It has been shown to disrupt calcineurin (also known as CaN or phosphatase 2B)-mediated signal transduction in T lymphocytes. The compound interacts with its FK506-binding protein...
Endotoxin Level: <1.0EU per 1μg (determined by the LAL method). Formulation: Supplied as lyophilized form in PBS,pH7.4, containing 5% sucrose, 0.01% sarcosyl. Predicted isoelectric point: 7.9 Predicted Molecular Mass: 13.2kDa Accurate Molecular Mass: 17kDa as determined by SDS-PAGE reducingcon...