Intra- and interindividual variation in the pharmaco- kinetics of tacrolimus (FK506) in kidney transplant recipi- ents: importance of trough level as a practical indicator. Int J Urol. 1995;2:151-155.Ihara H, Shinkuma D, Ichikawa Y, Nojima M, Nagano S, Ikoma F. Intra- and ...
Solid Organ Transplantation: The KidneyInfluence of Hepatitis C Virus Infection on FK 506 Blood Levels in Renal Transplant Patients Author links open overlay panelC Manzanares A, M Moreno A, F Castellanos A, A Cubas A, J.C Herrero A, E Morales-Ruiz A, J Segura A, A Andres A, J.M ...
另外,鉴于FK506有效的免疫抑制作用,及早减量直至停用对糖代谢有影响的皮质激素,可能是减少PTDM的又一较好措施,这有待于进一步的临床研究。 参考文献 1 Vanrenterghem Y.Tacrolimus(FK506 )in kidney transplantation.Transplant Proc,1998,30:2171 2 John F.Neylan for the FK506 kidney tra nsplant study group....
探讨肾移植患者低FK506血药浓度与早期急性排斥发生的关系。方法 本文通过 EIISA方法检查来自30例肾移植患者349份血标本。根据血清肌酐的升高来判断器官排斥的发生,l2 例被考虑有排斥,其中5个病人通过活检确证,移植术后一个月或到第一次排斥的排斥患者与非排斥患 ...
Am J Transplant.2021; 21 (suppl 3). https://atcmeetingabstracts.com/abstract/pharmacokinetic-analysis-of-direct-acting-antiviral-use-on-weight-adjusted-fk506-trough-dose-ratios-in-obese-kidney-transplant-recipients/. Accessed May 6, 2025. ...
观察服用FK-506的肾移植术后患者血清细胞因子及生化指标,以评价机体免疫功能的改变及生化代谢变化。 方法 观察130例长期服用抗排斥药物FK-506的肾移植患者及80例正常人,清晨空腹抽血,30rain内分离血清,利用RANDOX 细胞因子芯片和EVIDENCE全自动芯片分析仪测定血清12项细胞因子;利用全自动生化分析仪及ROCHE试剂盒测定患者...
New morphological changes induced by FK506 in a short period in the rat kidney and the effect of superoxide dismutase and OKY-046 on THEM: the relationship of FK506 nephrotoxicity to lipid peroxidation and change in production of thromboxane A2 in the kidney Book Title Transplant International Off...
FK506 is a new FDA-approved immunosuppressant used for prevention of allograft rejection in, for example, liver and kidney transplantations. FK506 is inactive by itself and requires binding to an FK506 binding protein-12 (FKBP-12), or immunophilin, for activation. In this regard, FK506 is ...
28, 29, 30 Initially, an attempt was made to maintain FK506 whole blood levels in the range of 5 to 60 ng/mL. As data became available from larger studies in solid organ transplantation and from the concurrent marrow transplant study of patients with HLA-matched donors, FK506 levels were...
OPTN/SRTR 2015 annual data report: kidney. Am J Transplant. 2017;17(Suppl 1):21–116. Article PubMed PubMed Central Google Scholar Clipstone NA, Crabtree GR. Identification of calcineurin as a key signalling enzyme in T-lymphocyte activation. Nature. 1992;357:695–7. Article CAS PubMed ...