(redirected fromFirst order kinetics) therapeutic drug monitoring Clinical pharmacology The regular measurement of serum levels of drugs requiring close 'titration' of doses in order to ensure that there are sufficient levels in the blood to be therapeutically effective, while avoiding potentially toxic...
First order kinetics describes the most common time course of drug elimination. The amount eliminated within a time-interval is proportionate to the drug concentration in the blood. PharmacokineticsSpringer Berlin HeidelbergEncyclopedic Reference of Molecular Pharmacology...
Sarver, in Pharmacology, 2009 10.5.3.2 Overall First-Order Elimination Rate Constant If the elimination rate, metabolic rate, and excretion rate all follow first-order (or linear) kinetics, then the overall first-order elimination rate constant (k) can be written as (10.75)relim=k⋅Arem...
Pharmacometrics is the science of using in silico models to understand and generate new knowledge of the underlying processes of the drug-patient-disease interactions by interlinking the biology, physiology, and pharmacology. It is essential to learn, describe, and predict pharmacokinetics (PK) and ...
First Pass Effect In subject area:Pharmacology, Toxicology and Pharmaceutical Science First pass effect is a phenomenon in which the pharmacological agent gets absorbed at a specific location in the body that decrease the concentration of drug up to reaching its targeted sites or the systemic ...
The activity of free CbFDH readily decreased at 58 °C following the first-order kinetics with the half-life t1/2 of 27 min. The turbidity ... Makoto,Yoshimoto,Ryohei,... - 《Langmuir the Acs Journal of Surfaces & Colloids》 被引量: 5发表: 2015年 BNSF 2020 rail volume falls on pand...
the fraction of a dose eventually converted to a metabolite should be the same after each route of administration provided that the ingested drug is completely absorbed, is eliminated solely by metabolism in the liver, and has linear kinetics. Otherwise, the fraction of a dose administered that ...
- 《Clinical Pharmacology & Therapeutics》 被引量: 126发表: 1997年 Presystemic and systemic intestinal metabolism of fenoterol in the conscious rat. The intestinal and liver first pass metabolism of fenoterol.HBr (Berotec, Partusisten) was investigated in the conscious . Fenoterol plasma ...
The order of the four steps has been chosen for processing efficiency, but could be executed in any order. The resulting phenotype profiles are used to construct train and test sets, which in turn are used to learn and evaluate our predictive model. The numbers of publications that come ...
Regarding future prospects in this area, due to the multifactorial nature of epilepsy, a multidisciplinary approach integrating research in genetics, neuroscience, pharmacology and other fields is essential to advance the development of new therapies. Rational antiepileptic drug design for such a complex ...