(redirected fromFirst order kinetics) therapeutic drug monitoring Clinical pharmacology The regular measurement of serum levels of drugs requiring close 'titration' of doses in order to ensure that there are sufficient levels in the blood to be therapeutically effective, while avoiding potentially toxic...
Synonyms Kel Definition First-order elimination kinetics depends on the concentration of only one reactant (drug) and a constant fraction of the drug in the body is eliminated per unit time. The rate of elimination is proportional to the amount of drug in the body. The majority of drugs are...
ashrimp astaxanthin (MSA) was lower than the estimated production rate. The[translate] astudy demonstrated that astaxanthin extracted from shrimp byproducts using flaxseed oil[translate] ain MSA, fitted with first-order reaction kinetics model, showed that the degradation rate[translate]...
half-life of 3.2 ± 0.1days. These two independent investigators used data obtained from post-radical prostatectomy patients. They determined the metabolic clearance rate and the half-life of PSA, using a log linear regression model. The clearance of PSA followed first-order elimination kinetics. ...
genetic polymorphism etc. affecting the first-pass metabolism of a drug. Such considerations during the process ofdrug developmentare of prime importance to design an appropriate formulation with properexcipientsin order to enhance the bioavailability while maintaining the efficacy of drugs. The role of...
Efanesoctocog alfa (ALTUVIIIOTM; [antihemophilic factor (recombinant), Fc-VWF-XTEN fusion protein-ehtl]), a von Willebrand factor (VWF) independent, recomb
DXPS is one of the most important enzymes of the 2-C-methyl-d-erythritol 4-phosphate (MEP)-pathway and is a key target for the development of new anti-infective drugs to treat infections with multidrug-resistant bacteria. Here, we have applied our previously reported truncation approach and ...
Background Most patients with stage 2 hypertension require two or more antihypertensive agents in order to achieve the BP goals recommended in current trea... Dr,Dean,J.,... - 《American Journal of Cardiovascular Drugs》 被引量: 45发表: 2007年 Delocalization effects and charge reorganizations ...
Objective To establish a numerical method for the assay of plasma concentrations of drugs obeying the parallel first order and Michaelis-Menten clearance kinetics in the case of extravascular administration. 目的获得(一级并行)米氏消除药物血管外给药时的血药浓度近似值。 3. Objective: To establish a...
3. Synthesis of 21st century drugs against epilepsy 4. Conclusion and future prospects CRediT authorship contribution statement Declaration of competing interest Acknowledgements Data availability ReferencesShow full outline Figures (56) Show 50 more figures Tables (1) Table 1European...