(redirected fromFirst order kinetics) therapeutic drug monitoring Clinical pharmacology The regular measurement of serum levels of drugs requiring close 'titration' of doses in order to ensure that there are sufficient levels in the blood to be therapeutically effective, while avoiding potentially toxic...
First order kinetics describes the most common time course of drug elimination. The amount eliminated within a time-interval is proportionate to the drug concentration in the blood. PharmacokineticsSpringer Berlin HeidelbergEncyclopedic Reference of Molecular Pharmacology...
Sarver, in Pharmacology, 2009 10.5.3.2 Overall First-Order Elimination Rate Constant If the elimination rate, metabolic rate, and excretion rate all follow first-order (or linear) kinetics, then the overall first-order elimination rate constant (k) can be written as (10.75)relim=k⋅Arem...
In fact, in addition to the values of V, K12, K21, Kel, in the linear part, the full model needs to estimate Kint (internalization of the complex mAb-target), Kon (first-order association rate of the mAb with the target), Kd (dissociation constant of the mAb with the target), ...
First-order rate reactions can be described using the differential and integrated rate laws.First Order Reaction Chemical reactions are often discussed in terms of kinetics, or reaction rates. Many factors such as temperature, pressure, or the presence of catalysts affect kinetics. However, the main...
In all these works, gold nanoparticles were used to solve any problems in medicine and/or pharmacology. In [105], the process of the “clustering” of water molecules was considered and a new mechanism for the formation and destruction of giant water clusters with sizes from ten to hundreds ...
In subject area: Pharmacology, Toxicology and Pharmaceutical Science First pass effect is a phenomenon in which the pharmacological agent gets absorbed at a specific location in the body that decrease the concentration of drug up to reaching its targeted sites or the systemic circulation. ...
The activity of free CbFDH readily decreased at 58 °C following the first-order kinetics with the half-life t1/2 of 27 min. The turbidity ... Makoto,Yoshimoto,Ryohei,... - 《Langmuir the Acs Journal of Surfaces & Colloids》 被引量: 5发表: 2015年 BNSF 2020 rail volume falls on pand...
absorbed, is eliminated solely by metabolism in the liver, and has linear kinetics. Otherwise, the fraction of a dose administered that is converted to a metabolite may vary with route of administration (e.g. with isoprenaline and salbutamol). Variation in the concentration ratios between parent ...
first-order absorption process plus a loss by presystemic metabolism with Michaelis-Menten kinetics, suggesting the presence of a saturable first-pass effect... H Colom,J Pruñonosa,C Peraire,... - 《J Pharmacokinet Biopharm》 被引量: 13发表: 1999年 DESIGN, DEVELOPMENT AND EVALUATION OF SUMAT...