antipsychotic drugsschizophreniasymptomssecond generation antipsychoticsfirst generation antipsychoticsCONTEXT: Second-generation (atypical) antipsychotics (SGAs) are more expensive than first-generation (typical) antipsychotics (FGAs) but are perceived to be more effective, with fewer adverse effects, and ...
We searched PubMed for clinical studies that compared first-generation antipsychotics (FGAs; search terms “first-generation antipsychotic”, “conventional antipsychotic”, and “classical antipsychotic”) with second-generation antipsychotics (SGAs, search terms “second-generation antipsychotic”, and “aty...
The intraplantar injection of formalin produced a biphasic nociceptive response typical of this tonic pain model.85 These two distinct phases of spontaneous pain behaviors are proposed to reflect a short and direct effect of formalin on sensory receptors (acute phase, 0–9 min) and a longer ...
Methods Data from a historic cohort of consecutively admitted first-episode patients with schizophrenia treated with first-generation antipsychotics (FGAs) were compared with an age and sex matched series of consecutive first-episode patients treated only with second-generation antipsychotics (SGAs). Rates...
摘要: Background: Studies on therapeutic drug monitoring (TDM) of second-generation antipsychotics (SGAs) have provided conflicting results regarding the association between dose, plasma... 查看全部>>关键词: first-episode antipsychotic agents drug monitoring pharmacokinetics drug effects ...
The increase of pallidal volume seen in MIPT patients, together with the correlation between increased pallidal GMV and symptom improvement between baseline and 3 months, are consistent with a putative neuroprotective effect of second-generation antipsychotic medication (Fig.1d). Larger pallidal volumes...
The main reason for antipsychotic non-adherence are safety and tolerability issues, as well as lack of insight associated with psychosis. Although second generation antipsychotics are frequently used in treatment of patients diagnosed with schizophrenia, they are associated with a high risk of adverse ...
Aripiprazole is said to be one of a new generation of atypical antipsychotics with good antipsychotic properties and minimal adverse effects. Objectives To ... HG El-Sayeh,C Morganti - 《Cochrane Database of Systematic Reviews》 被引量: 380发表: 2003年 Metabolism of atypical antipsychotics: invol...
Inadequate response to antidepressant therapy (ADT) is common in major depressive disorder (MDD); atypical antipsychotic (AA) adjunctive therapy may be effective for these patients. This study aimed to compare healthcare resource utilization (HRU) and costs between patients initiating the AA cariprazine...
Few studies have assessed the comparative efficacy and safety of atypical and typical antipsychotic medications in patients within their first episode of psychosis. This study examined the effectiveness of the atypical antipsychotic olan... R Zipursky,H Gu,AI Green,... - 《Schizophrenia Research》 ...